Evidence map›Paper›PMID 27268956›Full record

ArticleTissue engineering. Part A2016

Growth Factor-Mediated Migration of Bone Marrow Progenitor Cells for Accelerated Scaffold Recruitment.

Paul H Liebesny, Sangwon Byun, Han-Hwa Hung, James R Pancoast, Keri A Mroszczyk, Whitney T Young, Richard T Lee, David D Frisbie, John D Kisiday, Alan J Grodzinsky

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tissue engineering. Part A, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Trypsin Pre-Treatment Combined With Growth Factor Functionalized Self-Assembling Peptide Hydrogel Improves Cartilage Repair in Rabbit Model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019
    Article
  8. Review
  9. Review
  10. Article
  11. Current Challenges in Translating Tissue-Engineered Heart Valves.Current treatment options in cardiovascular medicine · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Paul H Liebesny1 Department of Biological Engineering, Massachusetts Institute of Technology , Cambridge, Massachusetts.
Sangwon Byun1 Department of Biological Engineering, Massachusetts Institute of Technology , Cambridge, Massachusetts.
Han-Hwa Hung1 Department of Biological Engineering, Massachusetts Institute of Technology , Cambridge, Massachusetts.
James R Pancoast2 Brigham and Women's Hospital , Boston, Massachusetts.
Keri A Mroszczyk3 Department of Mechanical Engineering, Massachusetts Institute of Technology , Cambridge, Massachusetts.
Whitney T Young3 Department of Mechanical Engineering, Massachusetts Institute of Technology , Cambridge, Massachusetts.
Richard T Lee2 Brigham and Women's Hospital , Boston, Massachusetts.
David D Frisbie4 Colorado State University , Orthopaedic Research Center, Fort Collins, Colorado.
John D Kisiday4 Colorado State University , Orthopaedic Research Center, Fort Collins, Colorado.
Alan J Grodzinsky1 Department of Biological Engineering, Massachusetts Institute of Technology , Cambridge, Massachusetts.
Massachusetts Institute of Technology · USBrigham and Women's Hospital · USColorado State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tissue engineering approaches using growth factor-functionalized acellular scaffolds to support and guide repair driven by endogenous cells are thought to require a careful balance between cell recruitment and growth factor release kinetics. The objective of this study was to identify a growth factor combination that accelerates progenitor cell migration into self-assembling peptide hydrogels in the context of cartilage defect repair. A novel 3D gel-to-gel migration assay enabled quantification of the chemotactic impact of platelet-derived growth factor-BB (PDGF-BB), heparin-binding insulin-like growth factor-1 (HB-IGF-1), and transforming growth factor-β1 (TGF-β1) on progenitor cells derived from subchondral bovine trabecular bone (bone-marrow progenitor cells, BM-PCs) encapsulated in the peptide hydrogel [KLDL]3. Only the combination of PDGF-BB and TGF-β1 stimulated significant migration of BM-PCs over a 4-day period, measured by confocal microscopy. Both PDGF-BB and TGF-β1 were slowly released from the gel, as measured using their (125)I-labeled forms, and they remained significantly present in the gel at 4 days. In the context of augmenting microfracture surgery for cartilage repair, our strategy of delivering chemotactic and proanabolic growth factors in KLD may provide the necessary local stimulus to help increase defect cellularity, providing more cells to generate repair tissue.

Indexed as

AnimalsBecaplerminBone Marrow CellsCattleCell MovementInsulin-Like Growth Factor IProto-Oncogene Proteins c-sisStem CellsTissue ScaffoldsTransforming Growth Factor beta1BecaplerminInsulin-Like Growth Factor IProto-Oncogene Proteins c-sisTransforming Growth Factor beta1

Identifiers

PMID27268956
PMCPMC4948211
OpenAlexW2474425405

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.