ArticleBiosensors & bioelectronics2017
Enhanced dopamine detection sensitivity by PEDOT/graphene oxide coating on in vivo carbon fiber electrodes.
Article in Biosensors & bioelectronics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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The trial behind it
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Who cites it
61 citing papers in PubMed.
- Boron-Doped Nano-Crystalline Coated Carbon Fibers for Phasic Dopamine Sensing.Advanced healthcare materials · 2026Article
- Recent advances of in situ and in vivo electrochemical analysis of brain chemistry at micro- and nanoscale.QRB discovery · 2026Review
- Novel Amperometric Sensor Based on Glassy Graphene for Flow Injection Analysis.Sensors (Basel, Switzerland) · 2025Article
- Stabilized carbon coating on microelectrodes for scalable and interoperable neurotransmitter sensing.Nature communications · 2025Article
- Unveiling the PEDOT-polypyrrole hybrid electrode for the electrochemical sensing of dopamine.Scientific reports · 2025Article
- Glassy Carbon Fiber-like Multielectrode Arrays for Neurochemical Sensing and Electrophysiology Recording.Advanced materials technologies · 2025Article
- Recent Progress in Flexible Microelectrode Arrays for Combined Electrophysiological and Electrochemical Sensing.Biosensors · 2025Review
- Carbon microelectrodes for the measurement of neurotransmitters with fast-scan cyclic voltammetry: methodology and applications.Frontiers in bioengineering and biotechnology · 2025Review
- Enhanced Electrochemiluminescence Detection of Dopamine Using Antifouling PEDOT-Modified SPEs for Complex Biological Samples.ACS measurement science au · 2024Article
- Mechanistic Insight into Intestinal α-Synuclein Aggregation in Parkinson's Disease Using a Laser-Printed Electrochemical Sensor.ACS chemical neuroscience · 2024Article
- Multifunctional Nanomaterials for Advancing Neural Interfaces: Recording, Stimulation, and Beyond.Accounts of chemical research · 2024Review
- PEDOT/CNT Flexible MEAs Reveal New Insights into the Clock Gene's Role in Dopamine Dynamics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Surface-Roughened Graphene Oxide Microfibers Enhance Electrochemical Reversibility.Langmuir : the ACS journal of surfaces and colloids · 2024Article
- Intracellular neural control of an active feeding structure in Aplysia using a carbon fiber electrode array.Journal of neuroscience methods · 2024Article
- Waste Coffee Ground-Derived Porous Carbon for Neurochemical Detection.ACS sensors · 2024Article
- Advancements in Brain Research: The In Vivo/In Vitro Electrochemical Detection of Neurochemicals.Biosensors · 2024Review
- Editors' Choice-Review-The Future of Carbon-Based Neurochemical Sensing: A Critical Perspective.ECS sensors plus · 2023Review
- Conductive Polymers and Their Nanocomposites: Application Features in Biosensors and Biofuel Cells.Polymers · 2023Review
- Electrochemical sensor based on 3D-printed substrate by masked stereolithography (MSLA): a new, cheap, robust and sustainable approach for simple production of analytical platforms.Mikrochimica acta · 2023Article
- Design, Characterization, and In Vivo Application of Multi-Conductive Layer Organic Electrocorticography Probes.ACS applied materials & interfaces · 2023Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
Abstract
Dopamine (DA) is a monoamine neurotransmitter responsible for regulating a variety of vital life functions. In vivo detection of DA poses a challenge due to the low concentration and high speed of physiological signaling. Fast scan cyclic voltammetry at carbon fiber microelectrodes (CFEs) is an effective method to monitor real-time in vivo DA signaling, however the sensitivity is somewhat limited. Electrodeposition of poly(3,4-ethylene dioxythiophene) (PEDOT)/graphene oxide (GO) onto the CFE surface is shown to increase the sensitivity and lower the limit of detection for DA compared to bare CFEs. Thicker PEDOT/GO coatings demonstrate higher sensitivities for DA, but display the negative drawback of slow adsorption and electron transfer kinetics. The moderate thickness resulting from 25 s electrodeposition of PEDOT/GO produces the optimal electrode, exhibiting an 880% increase in sensitivity, a 50% decrease in limit of detection and minimally altered electrode kinetics. PEDOT/GO coated electrodes rapidly and robustly detect DA, both in solution and in the rat dorsal striatum. This increase in DA sensitivity is likely due to increasing the electrode surface area with a PEDOT/GO coating and improved adsorption of DA's oxidation product (DA-o-quinone). Increasing DA sensitivity without compromising electrode kinetics is expected to significantly improve our understanding of the DA function in vivo.
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