Evidence map›Paper›PMID 27267840›Full record

ArticleTranslational oncology2016

Evaluating Changes to Blood-Brain Barrier Integrity in Brain Metastasis over Time and after Radiation Treatment.

Donna H Murrell, Niloufar Zarghami, Michael D Jensen, Ann F Chambers, Eugene Wong, Paula J Foster

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. The blood-tumour barrier in cancer biology and therapy.Nature reviews. Clinical oncology · 2021
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Therapeutics for Brain Metastases, v3.Clinical cancer research : an official journal of the American Association for Cancer Research · 2016
    Article
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Donna H MurrellImaging Research Laboratories, Robarts Research Institute, London, ON, Canada; Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. Electronic address: dmurrell@robarts.ca.
Niloufar ZarghamiDepartment of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. Electronic address: nzargham@uwo.ca.
Michael D JensenDepartment of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. Electronic address: mjensen4@uwo.ca.
Ann F ChambersDepartment of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; London Regional Cancer Program, London Health Sciences Centre, London, ON, Canada. Electronic address: Ann.Chambers@lhsc.on.ca.
Eugene WongDepartment of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; London Regional Cancer Program, London Health Sciences Centre, London, ON, Canada. Electronic address: ewong4@uwo.ca.
Paula J FosterImaging Research Laboratories, Robarts Research Institute, London, ON, Canada; Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. Electronic address: pfoster@robarts.ca.
Western University · CARobarts Clinical Trials · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe incidence of brain metastasis due to breast cancer is increasing, and prognosis is poor. Treatment is challenging because the blood-brain barrier (BBB) limits efficacy of systemic therapies. In this work, we develop a clinically relevant whole brain radiotherapy (WBRT) plan to investigate the impact of radiation on brain metastasis development and BBB permeability in a murine model. We hypothesize that radiotherapy will decrease tumor burden and increase tumor permeability, which could offer a mechanism to increase drug uptake in brain metastases.

methodsContrast-enhanced magnetic resonance imaging (MRI) and high-resolution anatomical MRI were used to evaluate BBB integrity associated with brain metastases due to breast cancer in the MDA-MB-231-BR-HER2 model during their natural development. Novel image-guided microirradiation technology was employed to develop WBRT treatment plans and to investigate if this altered brain metastatic growth or permeability. Histology and immunohistochemistry were performed on whole brain slices corresponding with MRI to validate and further investigate radiological findings.

resultsHerein, we show successful implementation of microirradiation technology that can deliver WBRT to small animals. We further report that WBRT following diagnosis of brain metastasis can mitigate, but not eliminate, tumor growth in the MDA-MB-231-BR-HER2 model. Moreover, radiotherapy did not impact BBB permeability associated with metastases.

conclusionsClinically relevant WBRT is not curative when delivered after MRI-detectable tumors have developed in this model. A dose of 20 Gy in 2 fractions was not sufficient to increase tumor permeability such that it could be used as a method to increase systemic drug uptake in brain metastasis.

Identifiers

PMID27267840
PMCPMC4907987
OpenAlexW2395188462

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.