ArticleProceedings of the National Academy of Sciences of the United States of America1989
Molecular cloning and amino acid sequence of human plakoglobin, the common junctional plaque protein.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed, 218 citations in OpenAlex.
- Antitumor Activity of a Novel LAIR1 Antagonist in Combination with Anti-PD1 to Treat Collagen-Rich Solid Tumors.Molecular cancer therapeutics · 2024Article
- A signaling hub of insulin receptor, dystrophin glycoprotein complex and plakoglobin regulates muscle size.Nature communications · 2020Article
- ARMc8 indicates aggressive colon cancers and promotes invasiveness and migration of colon cancer cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- ARMC8α promotes proliferation and invasion of non-small cell lung cancer cells by activating the canonical Wnt signaling pathway.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Beyond cell adhesion: the role of armadillo proteins in the heart.Cellular signalling · 2013Review
- The intercellular organization of the two muscular systems in the adult salmonid heart, the compact and the spongy myocardium.Journal of anatomy · 2009Article
- Discovering the molecular components of intercellular junctions--a historical view.Cold Spring Harbor perspectives in biology · 2009Review
- Quantitative proteomics analysis integrated with microarray data reveals that extracellular matrix proteins, catenins, and p53 binding protein 1 are important for chemotherapy response in ovarian cancers.Omics : a journal of integrative biology · 2009Article
- Differential expression pattern of protein ARVCF in nephron segments of human and mouse kidney.Histochemistry and cell biology · 2008Article
- The desmosome and pemphigus.Histochemistry and cell biology · 2008Review
- Candida albicans VAC8 is required for vacuolar inheritance and normal hyphal branching.Eukaryotic cell · 2006Article
- Candidate target genes for loss of heterozygosity on human chromosome 17q21.British journal of cancer · 2004Article
- The role of altered cell-cell communication in melanoma progression.Journal of molecular histology · 2004Review
- Downregulation of E-cadherin and Desmoglein 1 by autocrine hepatocyte growth factor during melanoma development.Oncogene · 2001Article
- A central role for the armadillo protein plakoglobin in the autoimmune disease pemphigus vulgaris.The Journal of cell biology · 2001Article
- Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin.Molecular and cellular biology · 2000Article
- Plakoglobin suppresses epithelial proliferation and hair growth in vivo.The Journal of cell biology · 2000Article
- Differential interaction of plakoglobin and beta-catenin with the ubiquitin-proteasome system.Oncogene · 2000Article
- Membrane-anchored plakoglobins have multiple mechanisms of action in Wnt signaling.Molecular biology of the cell · 1999Article
- N-Cadherin expression in human prostate carcinoma cell lines. An epithelial-mesenchymal transformation mediating adhesion withStromal cells.The American journal of pathology · 1999Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plakoglobin is a major cytoplasmic protein that occurs in a soluble and a membrane-associated form and is the only known constituent common to the submembranous plaques of both kinds of adhering junctions, the desmosomes and the intermediate junctions. Using a partial cDNA clone for bovine plakoglobin, we isolated cDNAs encoding human plakoglobin, determined its nucleotide sequence, and deduced the complete amino acid sequence. The polypeptide encoded by the cDNA was synthesized by in vitro transcription and translation and identified by its comigration with authentic plakoglobin in two-dimensional gel electrophoresis. The identity was further confirmed by comparison of the deduced sequence with the directly determined amino acid sequence of two fragments from bovine plakoglobin. Analysis of the plakoglobin sequence showed the protein (744 amino acids; 81,750 Da) to be unrelated to any other known proteins, highly conserved between human and bovine tissues, and characterized by numerous changes between hydrophilic and hydrophobic sections. Only one kind of plakoglobin mRNA (3.4 kilobases) was found in most tissues, but an additional mRNA (3.7 kilobases) was detected in certain human tumor cell lines. This longer mRNA may be represented by a second type of plakoglobin cDNA, which contains an insertion of 297 nucleotides in the 3' non-coding region.
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