ArticleProceedings of the National Academy of Sciences of the United States of America1989
Characterization of human cardiac myosin heavy chain genes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 102 citations in OpenAlex.
- Mutations of the beta myosin heavy chain gene in hypertrophic cardiomyopathy: critical functional sites determine prognosis.Heart (British Cardiac Society) · 2003Trial
- Immature and mature myocardium in the pathophysiology of hypertrophic cardiomyopathy.Journal of molecular and cellular cardiology plus · 2026Review
- Ohno-miRNAs: miRNA pairs derived from whole-genome duplication.PLoS computational biology · 2025Article
- MYH7 in cardiomyopathy and skeletal muscle myopathy.Molecular and cellular biochemistry · 2024Review
- Proliferation and Maturation: Janus and the Art of Cardiac Tissue Engineering.Circulation research · 2023Review
- Skeletal muscle myosin and cardiac myosin attenuate heparin's antithrombin-dependent anticoagulant activity.Journal of thrombosis and haemostasis : JTH · 2021Article
- Cardiac Myosin Promotes Thrombin Generation and Coagulation In Vitro and In Vivo.Arteriosclerosis, thrombosis, and vascular biology · 2020Article
- Sarcomeric Gene Variants and Their Role with Left Ventricular Dysfunction in Background of Coronary Artery Disease.Biomolecules · 2020Review
- The protective effect of Er-Xian decoction against myocardial injury in menopausal rat model.BMC complementary and alternative medicine · 2018Article
- Splicing Factor RBM20 Regulates Transcriptional Network of Titin Associated and Calcium Handling Genes in The Heart.International journal of biological sciences · 2018Article
- Functional Segregation within the Muscles of Aquatic Propulsion in the Asiatic Water Monitor (Varanus salvator).Frontiers in physiology · 2016Article
- Prospects for In Vitro Myofilament Maturation in Stem Cell-Derived Cardiac Myocytes.Biomarker insights · 2015Article
- Sarcomeric protein isoform transitions in cardiac muscle: a journey to heart failure.Biochimica et biophysica acta · 2015Review
- Emulsion electrospun nanofibers as substrates for cardiomyogenic differentiation of mesenchymal stem cells.Journal of materials science. Materials in medicine · 2013Article
- Developmental expression and cardiac transcriptional regulation of Myh7b, a third myosin heavy chain in the vertebrate heart.Cytoskeleton (Hoboken, N.J.) · 2012Article
- Article
- Physical interaction between TBX5 and MEF2C is required for early heart development.Molecular and cellular biology · 2009Article
- Repositioning of muscle-specific genes relative to the periphery of SC-35 domains during skeletal myogenesis.Molecular biology of the cell · 2004Article
- The myocardial protein S100A1 plays a role in the maintenance of normal gene expression in the adult heart.Molecular and cellular biochemistry · 2003Article
- Evidence for differential post-translational modifications of slow myosin heavy chain during murine skeletal muscle development.Journal of muscle research and cell motility · 2000Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have isolated and analyzed the structure of the genes coding for the alpha and beta forms of the human cardiac myosin heavy chain (MYHC). Detailed analysis of four overlapping MYHC genomic clones shows that the alpha-MYHC and beta-MYHC genes constitute a total length of 51 kilobases and are tandemly linked. The beta-MYHC-encoding gene, predominantly expressed in the normal human ventricle and also in slow-twitch skeletal muscle, is located 4.5 kilobases upstream of the alpha-MYHC-encoding gene, which is predominantly expressed in normal human atrium. We have determined the nucleotide sequences of the beta form of the MYHC gene, which is 100% homologous to the cardiac MYHC cDNA clone (pHMC3). It is unlikely that the divergence of a few nucleotide sequences from the cardiac beta-MYHC cDNA clone (pHMC3) reported in a MYHC cDNA clone (pSMHCZ) from skeletal muscle is due to a splicing mechanism. This finding suggests that the same beta form of the cardiac MYHC gene is expressed in both ventricular and slow-twitch skeletal muscle. The promoter regions of both alpha- and beta-MYHC genes, as well as the first four coding regions in the respective genes, have also been sequenced. The sequences in the 5'-flanking region of the alpha- and beta-MYHC-encoding genes diverge extensively from one another, suggesting that expression of the alpha- and beta-MYHC genes is independently regulated.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.