ArticleBMC pediatrics2016
Maternal and perinatal conditions and the risk of developing celiac disease during childhood.
Article in BMC pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05094232 (Epidemiologic Evolution of Coeliac Disease in Spain and Risk Factors Influencing Disease Prevalence), which is not on this map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Epidemiologic Evolution of Coeliac Disease in Spain and Risk Factors Influencing Disease Prevalence
Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Environmental Factors Associated With Celiac Disease in Children in Southeast Iran: A Case-Control Study.International journal of pediatrics · 2025Article
- Prevalence of delivery mode in an Italian nationwide cohort with celiac disease: a SIGENP multicenter retrospective study (the CD-deliver-IT).Italian journal of pediatrics · 2024Article
- How the Microbiota May Affect Celiac Disease and What We Can Do.Nutrients · 2024Review
- Five-year follow-up of new cases after a coeliac disease mass screening.Archives of disease in childhood · 2022Article
- Cesarean delivery and risk of hospitalization for autoimmune disorders before 14 years of age.European journal of pediatrics · 2021Article
- Family socio-economic status and childhood coeliac disease seem to be unrelated-A cross-sectional screening study.Acta paediatrica (Oslo, Norway : 1992) · 2021Article
- Role of the gut microbiota in the pathogenesis of coeliac disease and potential therapeutic implications.European journal of nutrition · 2020Review
- Childhood disability and its associated perinatal characteristics in Bao'an district of Shenzhen, China.BMC public health · 2020Article
- The Gut Microbiota in Celiac Disease and probiotics.Nutrients · 2019Review
- Smoking in pregnancy, cord blood cotinine and risk of celiac disease diagnosis in offspring.European journal of epidemiology · 2019Article
- Potential risk factors for celiac disease in childhood: a case-control epidemiological survey.Clinical and experimental gastroenterology · 2019Article
- Effect of childhood coeliac disease on ninth grade school performance: evidence from a population-based study.Archives of disease in childhood · 2018Article
- Mode of delivery is not associated with celiac disease.Clinical epidemiology · 2018Article
- Birth weight, sex, and celiac disease: a nationwide twin study.Clinical epidemiology · 2017Article
- Article
- Validation of celiac disease diagnoses recorded in the Danish National Patient Register using duodenal biopsies, celiac disease-specific antibodies, and human leukocyte-antigen genotypes.Clinical epidemiology · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCeliac disease (CD) is increasing worldwide, which might be due to the changing environmental and lifestyle exposures. We aimed to explore how conditions related to maternity, delivery and the neonatal period influence CD onset during childhood.
methodsUsing Sweden's national registers we had access to information on 1 912 204 children born between 1991 and 2009, 6 596 of whom developed CD before 15 years of age. Logistic regression analyses were performed to determine how CD is associated with maternity, delivery and the neonatal period.
resultsRegardless of sex, a reduction in CD risk was observed in children born to mothers aged ≥35 years (odds ratio [OR] 0.8; 95 % confidence interval [CI] 0.7-0.9) and with high maternal income (OR 0.9; 95 % CI 0.8-0.9). Being a second-born child, however, was positively associated with CD. Among boys, elective caesarean delivery increased the risk of CD (OR 1.2; 95 % CI 1.0-1.4), while maternal overweight (OR 0.9; 95 % CI 0.8-0.9), premature rupture of the membrane (OR 0.4; 95 % CI 0.2-0.8) and low birth weight showed a negative association. Girls had an increased CD risk compared to boys and in girls the risk was increased by repeated maternal urinary tract infections (OR 1.1; 95 % CI 1.0-1.2).
conclusionsElective caesarean delivery and repeated maternal urinary tract infections during pregnancy are associated with increased risk of CD onset during childhood, suggesting the role of dysbiosis during early life. High maternal age and high income reduced the risk of CD, which might be due to infant-feeding practices and life style.
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