SynthesisThyroid : official journal of the American Thyroid Association2016
New American Thyroid Association Sonographic Patterns for Thyroid Nodules Perform Well in Medullary Thyroid Carcinoma: Institutional Experience, Systematic Review, and Meta-Analysis.
Synthesis in Thyroid : official journal of the American Thyroid Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Role of the calcium stimulation test in diagnosing medullary thyroid cancer: is it adequate to achieve a diagnosis in both sexes? An individual patient data meta-analysis.European thyroid journal · 2025Pooled it
- Pooled it
- Suboptimal accuracy of ultrasound and ultrasound-based risk stratification systems in detecting medullary thyroid carcinoma should not be overlooked. Findings from a systematic review with meta-analysis.Clinical endocrinology · 2022Pooled it
- Ultrasound-based radiomics for prediction of lateral neck lymph node metastasis in patients with medullary thyroid cancer.Gland surgery · 2026Article
- Preoperative identification of the risk factors of cervical lymph node metastasis in medullary thyroid carcinoma.Frontiers in endocrinology · 2025Article
- The value and sensitivity of contrast-enhanced ultrasonography combined with fine-needle aspiration biopsy in the diagnosis of thyroid nodules.Scientific reports · 2024Article
- Diagnostic Efficiency of ACR-TIRADS Score for Differentiating Benign and Malignant Thyroid Nodules of Various Pathological Types.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- Molecular imaging and related therapeutic options for medullary thyroid carcinoma: state of the art and future opportunities.Reviews in endocrine & metabolic disorders · 2024Review
- Appropriate and mindful measurement of serum calcitonin in patients with thyroid nodules. A white paper.Endocrine · 2024Article
- Using preoperative ultrasound vascularity characteristics to estimate medullary thyroid cancer.Cancer imaging : the official publication of the International Cancer Imaging Society · 2023Article
- Comparison of the diagnostic performance and clinical role of different ultrasound-based thyroid malignancy risk stratification systems for medullary thyroid carcinoma.Quantitative imaging in medicine and surgery · 2023Article
- Clinical diagnostic value of American College of Radiology thyroid imaging report and data system in different kinds of thyroid nodules.BMC endocrine disorders · 2022Article
- Ultrasound features of medullary thyroid cancer as predictors of biological behavior.Cancer imaging : the official publication of the International Cancer Imaging Society · 2021Article
- Risk Stratification in Patients With Follicular Neoplasm on Cytology: Use of Quantitative Characteristics and Sonographic Patterns.Frontiers in endocrinology · 2021Article
- EU-TIRADS-Based Omission of Fine-Needle Aspiration and Cytology from Thyroid Nodules Overlooks a Substantial Number of Follicular Thyroid Cancers.International journal of endocrinology · 2021Article
- Medullary thyroid carcinoma: recent advances in identification, treatment, and prognosis.Therapeutic advances in endocrinology and metabolism · 2021Review
- Molecular Aspects of Thyroid Calcification.International journal of molecular sciences · 2020Review
- Medullary thyroid cancer: epidemiological pattern and factors contributing to recurrence and metastasis.Annals of the Royal College of Surgeons of England · 2020Article
- Contemporary Thyroid Nodule Evaluation and Management.The Journal of clinical endocrinology and metabolism · 2020Review
- Diagnostic Performance of Neck Ultrasonography in the Preoperative Evaluation for Extrathyroidal Extension of Suspicious Thyroid Nodules.World journal of surgery · 2020Observational
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe 2015 American Thyroid Association (ATA) thyroid nodule guidelines recommend selecting nodules for biopsy based on a sonographic pattern classification. These patterns were developed based on features of differentiated thyroid cancer. This study aimed to evaluate the performance and the inter-observer agreement of this classification system in medullary thyroid carcinoma (MTC).
methodsThe medical records of all patients with MTC evaluated at the authors' institution between 1998 and 2014 were retrospectively reviewed. Only patients with presurgical thyroid ultrasound available for review were included in the study. Five independent reviewers assessed the stored ultrasound images for composition, echogenicity, margins, presence of calcifications, and extrathyroidal extension for each nodule. The presence of suspicious lymph nodes was also evaluated when presurgical lateral neck ultrasound was available for review. Each nodule was classified according to the ATA sonographic patterns. Inter-observer agreement was calculated for each sonographic feature and for the sonographic patterns. To validate the findings, a systematic review of the literature and meta-analysis on the sonographic features of MTC was conducted.
resultsIn this institutional cohort, the inter-observer agreement for individual sonographic features was moderate to good (κ = 0.45-0.71), and for the ATA classification it was good (κ = 0.72). Ninety-seven percent (29/30) of the MTCs were classified in the intermediate or high suspicion patterns. A total of 249 MTCs were included in the meta-analysis. Based on pooled frequencies for solid composition and hypoechogenicity, >95% of MTCs would be classified at least in the intermediate suspicion pattern, warranting the lowest-size threshold for biopsy (≥1 cm).
conclusionsThe sonographic patterns proposed by the ATA perform well in MTC, and inter-observer agreement is good to very good.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.