ArticleParasites & vectors2016
T follicular helper cells in patients with acute schistosomiasis.
Article in Parasites & vectors, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- IL-21 silencing inhibits the proliferation, growth, and migration of colorectal cancer cells via suppressing phosphorylation of ERK1/2 and STAT3.Biological research · 2026Article
- Advances in the study of the interaction between schistosome infections and the host's intestinal microorganisms.Parasites & vectors · 2024Review
- Schistosoma mansoni infection alters the host pre-vaccination environment resulting in blunted Hepatitis B vaccination immune responses.PLoS neglected tropical diseases · 2023Article
- Identification and Characterization of Antigenic Properties ofPathogens (Basel, Switzerland) · 2022Article
- The Road to Elimination: Current State of Schistosomiasis Research and Progress Towards the End Game.Frontiers in immunology · 2022Review
- Higher frequency of circulating Vδ1 γδT cells in patients with advanced schistosomiasis.Parasite immunology · 2021Article
- Granulocytic myeloid-derived suppressor cells inhibit T follicular helper cells during experimental Schistosoma japonicum infection.Parasites & vectors · 2021Article
- Circulating Tfh cell and subsets distribution are associated with low-responsiveness to hepatitis B vaccination.Molecular medicine (Cambridge, Mass.) · 2021Article
- Alteration of the fecal microbiota in Chinese patients with Schistosoma japonicum infection.Parasite (Paris, France) · 2021Article
- T Lymphocyte-Mediated Liver Immunopathology of Schistosomiasis.Frontiers in immunology · 2020Review
- Interleukin (IL)-21 in Inflammation and Immunity During Parasitic Diseases.Frontiers in cellular and infection microbiology · 2019Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of T follicular helper (Tfh) cells in schistosome infection is not fully defined. In a previous study, a higher frequency of circulating PD-1(+)CXCR5(+)CD4(+) Tfh cells was observed in patients with chronic schistosomiasis relative to healthy controls (HCs) and it correlated positively with the level of soluble egg antigen (SEA) specific antibodies in serum. However, the function of Tfh cells in patients with acute schistosomiasis remains elusive; this was investigated in the present study.
methodsThe frequency of circulating Tfh cells and the expression of inducible T cell co-stimulator (ICOS), programmed cell death 1 (PD-1) and B cell subsets were analyzed in 12 patients with acute schistosomiasis and 10 HCs by flow cytometry. The expression of Bcl6, c-Maf and IL-21 mRNA were detected by quantitative real-time reverse transcriptase PCR (qRT-PCR). The concentration of serum IL-21 and IgG specific to Schistosoma japonicum antigen were then determined by enzyme linked immunosorbent assay (ELISA). Correlations between PD-1(+)CXCR5(+)CD4(+) Tfh cells, memory B cells and IgG specific to S. japonicum were analyzed by Spearman's rank correlation.
resultsThe frequency of PD-1(+)CXCR5(+)CD4(+) Tfh and memory B cells was increased in acute schistosomiasis patients relative to HCs. Moreover, the levels of IL-21 in serum and the expression of IL-21 mRNA were higher in acute schistosomiasis patients. However, there was no significant correlation between PD-1(+)CXCR5(+)CD4(+) Tfh cells, memory B cells and IgG specific to S. japonicum antigen in patients with acute schistosomiasis.
conclusionsPD-1(+)CXCR5(+)CD4(+) Tfh cells in peripheral blood are involved in the immune response of patients with acute schistosomiasis. Understanding the immunological mechanism is helpful for the development of vaccination strategies to control schistosomiasis.
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