ArticleThe International journal of neuroscience2017
The relationship of pro-inflammatory markers to vascular endothelial function after acute stroke.
Article in The International journal of neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Peripheral vascular function in stroke: systematic review and meta-analysis.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Pooled it
- TNF-α (G-308A) Polymorphism, Circulating Levels of TNF-α and IGF-1: Risk Factors for Ischemic Stroke-An Updated Meta-Analysis.Frontiers in aging neuroscience · 2022Pooled it
- Two weeks of remote ischemic conditioning improves brachial artery flow mediated dilation in chronic stroke survivors.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Trial
- Fitness After Stroke Trial (FAST): Protocol for a Preliminary Efficacy Study of Recumbent Stepper High-Intensity Interval Training.Artery research · 2026Article
- Fitness After Stroke Trial (FAST): Protocol for a Preliminary Efficacy Study of Recumbent Stepper High-Intensity Interval Training.Research square · 2025Article
- Impaired Peripheral Vascular Function Following Ischemic Stroke in Mice: Potential Insights into Blood Pressure Variations in the Post-Stroke Patient.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024Article
- Noninvasive estimation of skeletal muscle oxygen consumption rate and microvascular reactivity in chronic stroke survivors using near-infrared spectroscopy.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- The protective role of endothelial GLUT1 in ischemic stroke.Brain and behavior · 2024Review
- Amyloid-β: A potential mediator of aging-related vascular pathologies.Vascular pharmacology · 2023Review
- Article
- Cardiovascular disease risk is associated with middle cerebral artery blood flow velocity in older adults.Cardiopulmonary physical therapy journal · 2020Article
- Serum-Based Proteomics Reveals Lipid Metabolic and Immunoregulatory Dysregulation in Cervical Artery Dissection With Stroke.Frontiers in neurology · 2020Article
- Exercise intensity and middle cerebral artery dynamics in humans.Respiratory physiology & neurobiology · 2019Article
- Vascular Health is Associated with Amyloid-β in Cognitively Normal Older Adults.Journal of Alzheimer's disease : JAD · 2019Article
- Blunted cerebrovascular response is associated with elevated beta-amyloid.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- Effect of healthy aging and sex on middle cerebral artery blood velocity dynamics during moderate-intensity exercise.American journal of physiology. Heart and circulatory physiology · 2018Article
- Time Course of Flow-Mediated Dilation and Vascular Endothelial Growth Factor following Acute Stroke.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2018Article
- Dynamics of middle cerebral artery blood flow velocity during moderate-intensity exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Purpose/Aim: Data from chronic stroke studies have reported reduced blood flow and vascular endothelial function in the stroke-affected limb. It is unclear whether these differences are present early after stroke. First, we investigated whether vascular endothelial function in the stroke-affected limb would be different from healthy adults. Second, we examined whether between-limb differences in vascular endothelial function existed in the stroke-affected arm compared to the non-affected arm. Last, we tested whether reduced vascular endothelial function was related to pro-inflammatory markers that are present early after stroke. MATERIALS AND
methodsVascular endothelial function was assessed by flow-mediated dilation (FMD) in the brachial artery within 72 h post-stroke. All participants withheld medications from midnight until after the procedure. Ultrasound scans and blood draws for pro-inflammatory markers occurred on the same day between 7:30 am and 9:00 am.
resultsPeople with acute stroke had significantly lower FMD (4.2% ± 4.6%) than control participants (8.5% ± 5.2%, p = 0.037). Stroke participants had between-limb differences in FMD (4.2% ± 4.6% stroke-affected vs. 5.3% ± 4.4% non-affected, p = 0.02), whereas, the control participants did not. Of the pro-inflammatory markers, only vascular cell adhesion molecule-1(VCAM-1) had a significant relationship to FMD (stroke-affected limb, r = -0.62, p = 0.03; non-affected limb, r = -0.75, p = 0.005), but not tumor necrosis factor alpha nor interleukin-6.
conclusionsVascular endothelial function is reduced starting in the early stage of stroke recovery. People with higher levels of VCAM-1 had a lower FMD response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.