ArticleBMC infectious diseases2016
Clinical manifestations and cerebrospinal fluid status in ocular syphilis in HIV-Negative patients.
Article in BMC infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 28 citations in OpenAlex.
- Rapid Plasma Reagin Tests of Serum, Cerebrospinal Fluid, and Aqueous Humor of Patients With Ocular Syphilis and AIDS.Journal of ophthalmology · 2026Article
- Secondary Syphilis With Isolated Ocular Syphilis and Superimposed Corneal Abrasion: A Case Report.Cureus · 2025Article
- CDC Laboratory Recommendations for Syphilis Testing, United States, 2024.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2024Article
- Case report: Visual acuity loss as a warning sign of ocular syphilis: A retrospective analysis of 17 cases.Frontiers in medicine · 2022Article
- Older woman with abdominal pain and bilateral sequential vision loss due to syphilis.BMJ case reports · 2021Article
- Syphilis Laboratory Guidelines: Performance Characteristics of Nontreponemal Antibody Tests.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Review
- Eyes As the Window to Syphilis: A Rare Case of Ocular Syphilis As the Initial Presentation of Syphilis.Cureus · 2020Article
- Article
- Clinical Features and Treatments of Syphilitic Uveitis: A Systematic Review and Meta-Analysis.Journal of ophthalmology · 2017Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSyphilis with ocular involvement has reemerged as a critical health problem. The aim of the present study was to explore the clinical manifestations and cerebrospinal fluid (CSF) status in ocular syphilis in human immunodeficiency virus (HIV)-negative patients.
methodsThe clinical records of patients with ocular syphilis presenting to the Shanghai Xuhui Central Hospital in the period from January 2011 to December 2012 were retrospectively reviewed.
resultsThe median age of 25 HIV-negative patients with ocular syphilis was 53 years, 18 patients (72.0 %) were males and 7 (28.0 %) were females. None of them self-identified themselves as men who had sex with men (MSM). The ocular lesions included: uveitis (13 cases), optic neuropathy (6 cases), retinal vasculitis (5 cases), retinal detachment (3 cases), and neuroretinitis (4 cases). Serum toluidine red unheated serum test (TRUST) titer ranged from 1 to 512, with a median of 64. Overall, 18 (72.0 %) of the 25 patients had abnormal CSF results, 15 (60.0 %) CSF samples had elevated white blood cell counts, 13 (52.0 %) had elevated protein levels, and 9 (36.0 %) had reactive CSF Venereal Disease Research Laboratory (VDRL) test, respectively. Mann-Whitney U tests showed higher serum TRUST titer (>32) correlated with the abnormal CSF results.
conclusionsThe demographic characteristics of patients with ocular syphilis in this study were different from previous reports. The study showed a high CSF abnormal rate in HIV-negative patients. The recommendation for CSF examination from all patients with ocular syphilis, including HIV-negative cases, is strongly supported by the present data.
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