ArticleCortex; a journal devoted to the study of the nervous system and behavior2016
Default mode network differences between rigidity- and tremor-predominant Parkinson's disease.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.
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Who cites it
42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Cognitive function in different motor subtypes of Parkinson's disease: A systematic review and multilevel meta-analysis.Cognitive, affective & behavioral neuroscience · 2026Pooled it
- Altered brain connectivity in hyperkinetic movement disorders: A review of resting-state fMRI.NeuroImage. Clinical · 2023Pooled it
- Quantitative Susceptibility Mapping and Resting State Network Analyses in Parkinsonian Phenotypes-A Systematic Review of the Literature.Frontiers in neural circuits · 2019Pooled it
- A new paradigm for stratified cognitive assessment: fusing serum Raman spectroscopy and ensemble learning.Alzheimer's research & therapy · 2026Article
- Functional Connectivity and Volumetrics Improve Outcome Prediction for Deep Brain Stimulation in Parkinson's Disease.Movement disorders clinical practice · 2025Article
- Olfactory Network Functional Connectivity as a Marker for Parkinson's Disease Severity.Life (Basel, Switzerland) · 2025Article
- Using resting-state functional magnetic resonance imaging and contrastive learning to explore changes in the Parkinson's disease brain network and correlations with gait impairment.Quantitative imaging in medicine and surgery · 2025Article
- Advances in the fMRI analysis of the default mode network: a review.Brain structure & function · 2024Review
- Differences in gray matter atrophy and functional connectivity between motor subtypes of Parkinson's disease.Acta neurologica Belgica · 2024Article
- Data-Driven Discovery of Movement-Linked Heterogeneity in Neurodegenerative Diseases.Nature machine intelligence · 2024Article
- Dynamic properties in functional connectivity changes and striatal dopamine deficiency in Parkinson's disease.Human brain mapping · 2024Article
- Distinct changes in global brain synchronization in different motor subtypes of Parkinson's disease.Frontiers in neuroscience · 2023Article
- Cortical and subcortical morphological alterations in motor subtypes of Parkinson's disease.NPJ Parkinson's disease · 2022Article
- Differences in Brain Activity Between Dopa-Responsive and -Unresponsive Pain in Parkinson's Disease.Pain and therapy · 2022Article
- Nigral neuropathology of Parkinson's motor subtypes coincide with circuitopathies: a scoping review.Brain structure & function · 2022Article
- Antagonistic network signature of motor function in Parkinson's disease revealed by connectome-based predictive modeling.NPJ Parkinson's disease · 2022Article
- Cortico-striatal functional connectivity and cerebral small vessel disease: Contribution to mild Parkinsonian signs.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2022Article
- Differences in neuroanatomy and functional connectivity between motor subtypes of Parkinson's disease.Frontiers in neuroscience · 2022Article
- Different functional connectivity modes of the right fronto-insular cortex in akinetic-rigid and tremor-dominant Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- The default mode network and cognition in Parkinson's disease: A multimodal resting-state network approach.Human brain mapping · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundParkinson's disease (PD) traditionally is characterized by tremor, rigidity, and bradykinesia, although cognitive impairment also is a common symptom. The clinical presentation of PD is heterogeneous and associated with different risk factors for developing cognitive impairment. PD patients with primary akinetic/rigidity (PDAR) are more likely to develop cognitive deficits compared to those with tremor-predominant symptoms (PDT). Because cognitive impairment in PD appears to be related to changes in the default mode network (DMN), this study tested the hypothesis that DMN integrity is different between PDAR and PDT subtypes.
methodResting state fMRI (rs-fMRI) and whole brain volumetric data were obtained from 17 PDAR, 15 PDT and 24 healthy controls (HCs) using a 3T scanner. PD patients were matched closely to HCs for demographic and cognitive variables, and showed no symptoms of dementia. Voxel-based morphometry (VBM) was used to examine brain gray matter (GM) volume changes between groups. Independent component analysis (ICA) interrogated differences in the DMN among PDAR, PDT, and HC.
resultsThere was decreased activity in the left inferior parietal cortex (IPC) and the left posterior cingulate cortex (PCC) within the DMN between PDAR and both HC and PDT subjects, even after controlling for multiple comparisons, but not between PDT and HC. GM volume differences between groups were detected at a lower threshold (p < 0.001, uncorrected). Resting state activity in IPC and PCC were correlated with some measures of cognitive performance in PD but not in HC.
conclusionThis is the first study to demonstrate DMN differences between cognitively comparable PDAR and PDT subtypes. The DMN differences between PD and HC appear to be driven by the PDAR subtype. Further studies are warranted to understand the underlying neural mechanisms and their relevance to clinical and cognitive outcomes in PDAR and PDT subtypes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.