ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
Simultaneous production of amylases and proteases by Bacillus subtilis in brewery wastes.
Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 45 citations in OpenAlex.
- Probiotic Potential ofFoods (Basel, Switzerland) · 2026Article
- In silico and experimental characterization of a new polyextremophilic subtilisin-like protease from3 Biotech · 2024Article
- Exploring the Genomic Landscape ofCurrent issues in molecular biology · 2024Article
- Article
- A promising microbial α-amylase production, and purification from Bacillus cereus and its assessment as antibiofilm agent against Pseudomonas aeruginosa pathogen.Microbial cell factories · 2023Article
- Development and validation of a label-free method for measuring the collagen hydrolytic activity of protease.Bioprocess and biosystems engineering · 2021Article
- Article
- Statistical Based Bioprocess Design for Improved Production of Amylase from HalophilicMolecules (Basel, Switzerland) · 2021Article
- Consolidated Bioprocess for Bioethanol Production from Raw Flour ofMicroorganisms · 2019Article
- Formation of aromatic compounds precursors during fermentation of Criollo and Forastero cocoa.Heliyon · 2019Review
- New tricks of well-known aminoazoles in isocyanide-based multicomponent reactions and antibacterial activity of the compounds synthesized.Beilstein journal of organic chemistry · 2017Article
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5 authors at 2 institutions in 2 countries.
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Abstract
The simultaneous production of amylase (AA) and protease (PA) activity by Bacillus subtilis UO-01 in brewery wastes was studied by combining the response surface methodology with the kinetic study of the process. The optimum conditions (T=36.0°C and pH=6.8) for high biomass production (0.92g/L) were similar to the conditions (T=36.8°C and pH=6.6) for high AA synthesis (9.26EU/mL). However, the maximum PA level (9.77EU/mL) was obtained at pH 7.1 and 37.8°C. Under these conditions, a considerably high reduction (between 69.9 and 77.8%) of the initial chemical oxygen demand of the waste was achieved. In verification experiments under the optimized conditions for production of each enzyme, the AA and PA obtained after 15h of incubation were, respectively, 9.35 and 9.87EU/mL. By using the Luedeking and Piret model, both enzymes were classified as growth-associated metabolites. Protease production delay seemed to be related to the consumption of non-protein and protein nitrogen. These results indicate that the brewery waste could be successfully used for a high scale production of amylases and proteases at a low cost.
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