ArticleThe Annals of thoracic surgery2016
Missed Intrapulmonary Lymph Node Metastasis and Survival After Resection of Non-Small Cell Lung Cancer.
Article in The Annals of thoracic surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed.
- FDG-PET/CT data enhances machine learning prediction of occult lymph-node metastasis in lung adenocarcinoma.Journal of thoracic disease · 2026Article
- Prognosis of nodal micrometastasis in resectable pN0 non-small cell lung cancer.Frontiers in oncology · 2025Article
- Standardized intrapulmonary lymph node dissection in lung cancer specimens: A national Colombian analysis.JTCVS open · 2024Article
- Two Interventions on Pathologic Nodal Staging in a Population-Based Lung Cancer Resection Cohort.The Annals of thoracic surgery · 2024Article
- Frequency and predictive factors of nodal micro-metastasis (NMM) in resectable non-small cell lung cancer.Journal of thoracic disease · 2024Article
- Distinct impacts of radiological appearance on lymph node metastasis and prognosis based on solid size in clinical T1 non-small cell lung cancer.Respiratory research · 2024Article
- Association between number of dissected lymph nodes and survival in patients undergoing resection for clinical stage IA pure solid lung adenocarcinoma: a retrospective analysis.BMC pulmonary medicine · 2023Article
- A Comprehensive Comparison of Different Nodal Subclassification Methods in Surgically Resected Non-Small-Cell Lung Cancer Patients.Annals of surgical oncology · 2022Review
- Clinical impact of number of lymph nodes dissected on postoperative survival in node-negative small cell lung cancer.Frontiers in oncology · 2022Article
- Exploration of the optimal number of regional lymph nodes removed for resected N0 NSCLC patients: A population-based study.Frontiers in oncology · 2022Article
- A standard for hilar and intrapulmonary lymph node dissection and pathological examination in early non-small cell lung cancer.Translational lung cancer research · 2021Article
- Trends in Accuracy and Comprehensiveness of Pathology Reports for Resected NSCLC in a High Mortality Area of the United States.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2021Article
- Article
- The impact of an N1 lymph node examination in patients with early-stage non-small cell lung cancer: a retrospective cohort study.Journal of thoracic disease · 2021Article
- A large real-world cohort study of examined lymph node standards for adequate nodal staging in early non-small cell lung cancer.Translational lung cancer research · 2021Article
- Comparison of Lobectomy and Sublobar Resection for Stage IA Elderly NSCLC Patients (≥70 Years): A Population-Based Propensity Score Matching's Study.Frontiers in oncology · 2021Article
- Lymph node assessment in early stage non-small cell lung cancer lymph node dissection or sampling?General thoracic and cardiovascular surgery · 2020Review
- [Gefitinib inhibits glycolysis and induces programmed cell death in non-small cell lung cancer cells].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Article
- Beyond Margin Status: Population-Based Validation of the Proposed International Association for the Study of Lung Cancer Residual Tumor Classification Recategorization.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2020Article
- An Externally-Validated Dynamic Nomogram Based on Clinicopathological Characteristics for Evaluating the Risk of Lymph Node Metastasis in Small-Size Non-small Cell Lung Cancer.Frontiers in oncology · 2020Article
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Abstract
backgroundPathologic nodal stage is a key prognostic factor for patients with surgically resected lung cancer. We previously described the extent of missed intrapulmonary nodal metastasis in a cohort of patients treated at institutions in metropolitan Memphis, TN. With long-term follow-up, we now quantify the survival impact of missed nodal metastasis.
methodsWe conducted a prospective cohort study to evaluate inadvertently discarded lymph nodes in re-dissected remnant lung resection specimens from lung cancer patients. Retrieved material was histologically examined and classified as lymph nodes with and without metastasis. Survival information was obtained from hospital cancer registries. We plotted survival distributions with the use of the Kaplan-Meier method and evaluated them with proportional hazards models that controlled for important demographic and clinical factors.
resultsThe study included 110 patients who were 54% women and 69% white. Discarded lymph nodes with metastasis were found in 25 patients (23%). Patients with missed lymph node metastasis had an increased risk of death with an unadjusted hazard ratio of 2.0 (p = 0.06) and an adjusted hazard ratio of 1.4 (p = 0.45) compared with patients without missed lymph node metastasis. Patients with more than 2 missed lymph nodes with metastasis had 4.8 times the hazard of death (p = 0.0005) compared with patients without missed lymph node metastasis (adjusted hazard ratio 6.5, p = 0.0001).
conclusionsMetastasis to inadvertently discarded intrapulmonary lymph nodes from lung cancer resection specimens was associated with reduced survival. A more rigorous gross dissection protocol for lung cancer resection specimens may provide prognostically useful information.
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