Evidence map›Paper›PMID 27265707›Full record

ArticleWorld psychiatry : official journal of the World Psychiatric Association (WPA)2016

Diabetes mellitus in people with schizophrenia, bipolar disorder and major depressive disorder: a systematic review and large scale meta-analysis.

Davy Vancampfort, Christoph U Correll, Britta Galling, Michel Probst, Marc De Hert, Philip B Ward, Simon Rosenbaum, Fiona Gaughran, John Lally, Brendon Stubbs

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World psychiatry : official journal of the World Psychiatric Association (WPA), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 292 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
292citing papers in PubMed, 18 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

292 citing papers in PubMed, 18 syntheses or guidelines pooled it.

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  6. EPA guidance on lifestyle interventions for adults with severe mental illness: A meta-review of the evidence.European psychiatry : the journal of the Association of European Psychiatrists · 2024
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  12. Outcomes associated with different vaccines in individuals with bipolar disorder and impact on the current COVID-19 pandemic- a systematic review.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2022
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  17. The Effect of Muscular Strength on Depression Symptoms in Adults: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020
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  18. Schizophrenia.Deutsches Arzteblatt international · 2020
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232 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Davy VancampfortKU Leuven - University of Leuven, Department of Rehabilitation Sciences, Leuven, Belgium.
Christoph U CorrellZucker Hillside Hospital, Glen Oaks, NY, USA.
Britta GallingZucker Hillside Hospital, Glen Oaks, NY, USA.
Michel ProbstKU Leuven - University of Leuven, Department of Rehabilitation Sciences, Leuven, Belgium.
Marc De HertKU Leuven - University of Leuven, Z.org KU Leuven, Kortenberg, Belgium.
Philip B WardSchool of Psychiatry and Ingham Institute of Applied Medical Research, University of New South Wales, Sydney, Australia.
Simon RosenbaumSchool of Psychiatry and Ingham Institute of Applied Medical Research, University of New South Wales, Sydney, Australia.
Fiona GaughranDepartment of Psychosis Studies, Institute of Psychiatry, King's College London, London, UK.
John LallyDepartment of Psychosis Studies, Institute of Psychiatry, King's College London, London, UK.
Brendon StubbsDepartment of Psychosis Studies, Institute of Psychiatry, King's College London, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 2 diabetes mellitus (T2DM) is highly predictive of cardiovascular diseases and can have particularly deleterious health impacts in people with severe mental illness (SMI), i.e. schizophrenia, bipolar disorder or major depressive disorder. This meta-analysis aimed: a) to describe pooled frequencies of T2DM in people with SMI; b) to analyze the influence of demographic, illness and treatment variables as well as T2DM assessment methods; and c) to describe T2DM prevalence in studies directly comparing persons with each specific SMI diagnosis to general population samples. The trim and fill adjusted pooled T2DM prevalence among 438,245 people with SMI was 11.3% (95% CI: 10.0%-12.6%). In antipsychotic-naïve participants, the prevalence of T2DM was 2.9% (95% CI: 1.7%-4.8%). There were no significant diagnostic subgroup differences. A comparative meta-analysis established that multi-episode persons with SMI (N=133,470) were significantly more likely to have T2DM than matched controls (N=5,622,664): relative risk, RR=1.85, 95% CI: 1.45-2.37, p<0.001. The T2DM prevalence was consistently elevated in each of the three major diagnostic subgroups compared to matched controls. Higher T2DM prevalences were observed in women with SMI compared to men (RR=1.43, 95% CI: 1.20-1.69, p<0.001). Multi-episode (versus first-episode) status was the only significant predictor for T2DM in a multivariable meta-regression analysis (r(2) =0.52, p<0.001). The T2DM prevalence was higher in patients prescribed antipsychotics, except for aripriprazole and amisulpride. Routine screening and multidisciplinary management of T2DM is needed. T2DM risks of individual antipsychotic medications should be considered when making treatment choices.

Indexed as

antipsychoticsbipolar disorderDiabetes mellitusmajor depressive disorderschizophreniasevere mental illness

Identifiers

PMID27265707
PMCPMC4911762

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.