Evidence map›Paper›PMID 27265405›Full record

ReviewJournal of genetic counseling2016

Predispositions to Lymphoma: A Practical Review for Genetic Counselors.

Morgan Similuk, V Koneti Rao, Jane Churpek, Michael Lenardo

Open access · bronzeAbstract readReview
PubMed Publisher
In one paragraph

Review in Journal of genetic counseling, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Germline Genetic Predisposition to Hematologic Malignancy.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Morgan SimilukNational Institute of Allergy and Infectious Diseases, NIH, 10 Center Drive, Building 10, Room 12C103, Bethesda, MD, USA. morgan.similuk@nih.gov.
V Koneti RaoNational Institute of Allergy and Infectious Diseases, NIH, 10 Center Drive, Building 10, Room 12C103, Bethesda, MD, USA.
Jane ChurpekUniversity of Chicago Medical Center, Chicago, IL, USA.
Michael LenardoNational Institute of Allergy and Infectious Diseases, NIH, 10 Center Drive, Building 10, Room 12C103, Bethesda, MD, USA.
National Institute of Allergy and Infectious Diseases · USUniversity of Chicago Medical Center · US

Funding

Molecular Mechanisms Of The Autoimmune Lymphoproliferative Syndrome And Other Immunoregulatory DisordersZIAAI000769 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI SU, HELEN · 2009 to 2024
$16.7M
Clinical, Immunological and Genetic Analyses of ALPS and Related Immunedysregulatory DisordersZIAAI000732 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI RAO, V KONETI · 2009 to 2025
$10.5M
6 · The paper itself

Abstract

This review provides a synopsis for genetic counselors of the major concepts of lymphoma predisposition: genomic instability, immune deficiency, inappropriate lymphoproliferation, and chronic antigen stimulation. We discuss syndromes typifying each of these mechanisms. Importantly, our review of the genetic counseling literature reveals sparse discussion of genetically-based immune-mediated lymphoma predisposition, which we address in depth here. We aim to increase awareness among genetic counselors and colleagues in oncology about familial susceptibility and facilitate critical thinking about lymphoma risk assessment. Clinical application of this knowledge is aided by recommendations for collection of personal and family history to guide risk assessment and testing. Lastly, we include a special discussion of genetic counseling issues including perceptions of the context, nature, and magnitude of lymphoma risk, as well as coping with awareness of susceptibility to lymphoma.

Indexed as

Genetic CounselingGenetic Predisposition to DiseasePractice Guidelines as TopicFemaleGenetic TestingHumansLymphomaMaleRisk AssessmentCancerGenetic counselingHeredityImmunologyLymphomaMechanismPredispositionRisk assessment

Identifiers

PMID27265405
OpenAlexW2416261565

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.