Evidence map›Paper›PMID 27264687›Full record

ArticleCellular & molecular immunology2017

Novel exosome-targeted T-cell-based vaccine counteracts T-cell anergy and converts CTL exhaustion in chronic infection via CD40L signaling through the mTORC1 pathway.

Rong Wang, Aizhang Xu, Xueying Zhang, Jie Wu, Andrew Freywald, Jianqing Xu, Jim Xiang

Open access · bronzeAbstract read
In one paragraph

Article in Cellular & molecular immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
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  9. Article
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  11. Mesenchymal Stem Cells and Their Exocytotic Vesicles.International journal of molecular sciences · 2023
    Review
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  13. Review
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  15. Article
  16. Article
  17. Review
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  19. Vaccine delivery systems toward lymph nodes.Advanced drug delivery reviews · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Rong WangCancer Research Cluster, Saskatchewan Cancer Agency, Saskatoon, Saskatchewan, Canada S7N4H4.
Aizhang XuCancer Research Cluster, Saskatchewan Cancer Agency, Saskatoon, Saskatchewan, Canada S7N4H4.
Xueying ZhangCancer Research Cluster, Saskatchewan Cancer Agency, Saskatoon, Saskatchewan, Canada S7N4H4.
Jie WuCancer Research Cluster, Saskatchewan Cancer Agency, Saskatoon, Saskatchewan, Canada S7N4H4.
Andrew FreywaldDepartment of Pathology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E5.
Jianqing XuShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Jim XiangCancer Research Cluster, Saskatchewan Cancer Agency, Saskatoon, Saskatchewan, Canada S7N4H4.
Saskatchewan Cancer Agency · CAUniversity of Saskatchewan · CAShanghai Public Health Clinical Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CD8

Indexed as

AnimalsCD40 LigandCD8 AntigensChronic DiseaseClonal AnergyExosomesHumansLymphocyte ActivationMechanistic Target of Rapamycin Complex 1Melanoma, ExperimentalMiceMice, Inbred C57BLMice, TransgenicNeoplasms, ExperimentalSignal TransductionT-Lymphocytes, CytotoxicCD40 LigandCD8 AntigensMechanistic Target of Rapamycin Complex 1Viral Vaccines

Identifiers

PMID27264687
PMCPMC5518816
OpenAlexW2470077082

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.