Evidence map›Paper›PMID 27264532›Full record

ArticleCancer medicine2016

The impact of marital status at diagnosis on cancer survival in patients with differentiated thyroid cancer.

Rong-Liang Shi, Ning Qu, Zhong-Wu Lu, Tian Liao, Yi Gao, Qing-Hai Ji

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Article in Cancer medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.

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48citing papers in PubMed, 1 pooled it
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Rong-Liang ShiDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Ning QuDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Zhong-Wu LuDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Tian LiaoDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Yi GaoDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Qing-Hai JiDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies have revealed that marital status influences the prognosis of patients with various types of cancer. We evaluated the influence of marriage on the survival outcomes in differentiated thyroid cancer (DTC). The Surveillance, Epidemiology and End Results (SEER) database between 2002 and 2012 was used to compare cancer-specific mortality in different marital status, and in each sex, age, and stage stratification by multivariate Cox regression model. In total, 61,077 eligible patients were identified. The widowed group had the highest proportion of women, elderly patients (≥45 years), and advanced stage III/IV tumor (P = 0.001), but the total thyroidectomy (TT) performed and radioisotopes therapy rates were lower than those in the married group. Married patients had a better cancer-specific survival (CSS) than the unmarried (P < 0.05). Further analysis showed that widowed patients always presented the lowest CSS compared with other groups. Widowed patients had a significant increased risk for CSS compared with married patients in males [hazard ratio (HR) 2.72, 95% confidence interval (CI): 1.59-4.65, P = 0.001], females (HR 2.02, 95% CI: 2.24-4.06, P = 0.001), young patients (<45, HR 28.12, 95% CI: 3.48-227.25, P = 0.002), elderly patients (≥45, HR 28.12, 95% CI: 2.97, 95% CI: 2.30-3.83, P = 0.001), stage I (HR 8.44, 95% CI: 4.05-17.59, P = 0.001), stage II (HR 3.64, 95% CI: 1.30-10.20, P = 0.014), stage III (HR 2.27, 95% CI: 1.08-4.78, P = 0.031), and stage IV (HR 2.63, 95% CI: 1.94-3.57, P = 0.001). These results showed that unmarried status, especially for widowhood, increased the risk of cancer mortality in DTC patients.

Indexed as

Marital StatusAdultFemaleHumansMaleNeoplasm GradingNeoplasm StagingPopulation SurveillanceSEER ProgramSurvival AnalysisThyroid NeoplasmsUnited StatesDifferentiated thyroid cancermarital statusSEERsurvival analysis

Identifiers

PMID27264532
PMCPMC4898978

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.