Evidence map›Paper›PMID 27264387›Full record

SynthesisBJOG : an international journal of obstetrics and gynaecology2017

Maternal influenza and birth outcomes: systematic review of comparative studies.

D B Fell, D A Savitz, M S Kramer, B D Gessner, M A Katz, M Knight, J M Luteijn, H Marshall, N Bhat, M G Gravett and 2 more

Open access · hybridAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BJOG : an international journal of obstetrics and gynaecology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 7 pooled it
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 7 syntheses or guidelines pooled it, 151 citations in OpenAlex.

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  7. Maternal influenza and birth outcomes: systematic review of comparative studies.BJOG : an international journal of obstetrics and gynaecology · 2017
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25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 12 institutions in 7 countries.

D B FellDepartment of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada.
D A SavitzDepartment of Epidemiology, Brown University, Providence, RI, USA.
M S KramerDepartment of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada.
B D GessnerAgence de Médecine Préventive, Paris, France.
M A KatzIndependent Consultant, Tel Aviv, Israel.
M KnightNational Perinatal Epidemiology Unit, University of Oxford, Oxford, UK.
J M LuteijnQueen Mary University of London, London, UK.
H MarshallVaccinology and Immunology Research Trials Unit, Women's and Children's Hospital, North Adelaide, SA, Australia.
N BhatPATH, Seattle, WA, USA.
M G GravettDepartment of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA.
B SkidmoreIndependent Consultant, Ottawa, ON, Canada.
J R OrtizInitiative for Vaccine Research, World Health Organization, Geneva, Switzerland.
Agence de Médecine Préventive · FRAgricultural Research Institute of Ontario · CABrown University · USGlobal Alliance to Prevent Prematurity and Stillbirth · USIsrael Ports Development and Assets (Israel) · ILMcGill University · CAOldham Council · GBProgram for Appropriate Technology in Health · USQueen Mary University of London · GBUniversity of Adelaide · AUUniversity of Oxford · GBWorld Health Organization · CH

Funding

NCEZID CDC HHS U50 CK000431World Health Organization 001
6 · The paper itself

Abstract

backgroundAlthough pregnant women are considered at high risk for severe influenza disease, comparative studies of maternal influenza and birth outcomes have not been comprehensively summarised.

objectiveTo review comparative studies evaluating maternal influenza disease and birth outcomes. SEARCH STRATEGY: We searched bibliographic databases from inception to December 2014. SELECTION CRITERIA: Studies of preterm birth, small-for-gestational-age (SGA) birth or fetal death, comparing women with and without clinical influenza illness or laboratory-confirmed influenza infection during pregnancy. DATA COLLECTION AND ANALYSIS: Two reviewers independently abstracted data and assessed study quality. MAIN

resultsHeterogeneity across 16 studies reporting preterm birth precluded meta-analysis. In a subgroup of the highest-quality studies, two reported significantly increased preterm birth (risk ratios (RR) from 2.4 to 4.0) following severe 2009 pandemic H1N1 (pH1N1) influenza illness, whereas those assessing mild-to-moderate pH1N1 or seasonal influenza found no association. Five studies of SGA birth showed no discernible patterns with respect to influenza disease severity (pooled odds ratio 1.24; 95% CI 0.96-1.59). Two fetal death studies were of sufficient quality and size to permit meaningful interpretation. Both reported an increased risk of fetal death following maternal pH1N1 disease (RR 1.9 for mild-to-moderate disease and 4.2 for severe disease).

conclusionsComparative studies of preterm birth, SGA birth and fetal death following maternal influenza disease are limited in number and quality. An association between severe pH1N1 disease and preterm birth and fetal death was reported by several studies; however, these limited data do not permit firm conclusions on the magnitude of any association. TWEETABLE ABSTRACT: Comparative studies are limited in quality but suggest severe pandemic H1N1 influenza increases preterm birth.

Indexed as

Infant, Small for Gestational AgeAdultFemaleFetal DeathHumansInfant, NewbornInfluenza A Virus, H1N1 SubtypeInfluenza, HumanPregnancyPregnancy Complications, InfectiousPregnancy OutcomePremature BirthUnited KingdomFetal deathinfluenzapregnancypreterm birthsmall-for-gestational-age birthsystematic review

Identifiers

PMID27264387
PMCPMC5216449
OpenAlexW2464007962

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.