Evidence map›Paper›PMID 27264058›Full record

Trial reportOsteoarthritis and cartilage2016

The effect of vitamin D supplementation on knee osteoarthritis, the VIDEO study: a randomised controlled trial.

N K Arden, S Cro, S Sheard, C J Doré, A Bara, S A Tebbs, D J Hunter, S James, C Cooper, T W O'Neill and 3 more

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Osteoarthritis and cartilage, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03665116 (Effects of Arginine on Osteoarthritis), which is not on this map. Cited by 71 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 15 pooled it
15.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03665116 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Effects of Arginine on Osteoarthritis: A Pilot Clinical Trial

TypeinterventionalSponsorMemorial University of NewfoundlandRan2019 to 2024Enrolled38ConditionsKnee OsteoarthritisArmsL-arginine
3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 15 syntheses or guidelines pooled it, 134 citations in OpenAlex.

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  15. Vitamin D for the treatment of chronic painful conditions in adults.The Cochrane database of systematic reviews · 2015
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 1 country.

N K ArdenOxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Windmill Road, Oxford OX3 7LD, UK; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK; Arthritis Research UK Centre of Excellence for Sport, Injury, and Osteoarthritis, UK. Electronic address: Nigel.Arden@ndorms.ox.ac.uk.
S CroMRC Clinical Trials Unit at UCL, Institute of Clinical Trials & Methodology, Aviation House, 125 Kingsway, London WC2B 6NH, UK. Electronic address: s.cro@ucl.ac.uk.
S SheardOxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Windmill Road, Oxford OX3 7LD, UK. Electronic address: sally.sheard@isis.ox.ac.uk.
C J DoréMRC Clinical Trials Unit at UCL, Institute of Clinical Trials & Methodology, Aviation House, 125 Kingsway, London WC2B 6NH, UK. Electronic address: caroline.dore@ucl.ac.uk.
A BaraMRC Clinical Trials Unit at UCL, Institute of Clinical Trials & Methodology, Aviation House, 125 Kingsway, London WC2B 6NH, UK. Electronic address: a.bara@ucl.ac.uk.
S A TebbsMRC Clinical Trials Unit at UCL, Institute of Clinical Trials & Methodology, Aviation House, 125 Kingsway, London WC2B 6NH, UK. Electronic address: susan.tebbs@ucl.ac.uk.
D J HunterOxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Windmill Road, Oxford OX3 7LD, UK; Chromatic Innovation Limited, Leamington Spa, UK. Electronic address: d.j.hunter@gmail.com.
S JamesSt Richard's Hospital, Chichester, UK. Electronic address: samjames1@nhs.net.
C CooperOxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Windmill Road, Oxford OX3 7LD, UK; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK. Electronic address: cc@mrc.soton.ac.uk.
T W O'NeillArthritis Research UK Centre for Epidemiology, Institute of Inflammation and Repair, Faculty of Medical and Human Sciences, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK; NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. Electronic address: terence.o'neill@manchester.ac.uk.
A MacgregorNorwich Medical School, University of East Anglia, Norwich, UK. Electronic address: A.Macgregor@uea.ac.uk.
F BirrellInstitute of Cellular Medicine, Newcastle University, UK. Electronic address: fraser.birrell@newcastle.ac.uk.
R KeenRoyal National Orthopaedic Hospital, Stanmore, Middlesex, UK; Institute of Orthopaedics and Musculoskeletal Science, University College London, London, UK. Electronic address: Richard.Keen@rnoh.nhs.uk.
MRC Clinical Trials Unit at UCL · GBNuffield Orthopaedic Centre · GBSouthampton General Hospital · GBManchester Academic Health Science Centre · GBNewcastle University · GBRoyal National Orthopaedic Hospital · GBSt Richard's Hospital · GBUniversity of East Anglia · GB

Funding

Medical Research Council G0400491Medical Research Council MC_U122886349Medical Research Council MC_U147585819Medical Research Council MC_U147585824Medical Research Council MC_U147585827Medical Research Council MC_UP_A620_1014Medical Research Council MC_UU_12011/1Medical Research Council MC_UU_12023/14Medical Research Council MR/K006312/1
6 · The paper itself

Abstract

objectiveEpidemiological data suggest low serum 25-hydroxyvitamin D

methodA 3-year, double-blind, randomised, placebo-controlled trial of 474 patients aged over 50 with radiographically evident knee OA comparing 800 IU cholecalciferol daily with placebo. Primary outcome was difference in rate of medial joint space narrowing (JSN). Secondary outcomes included lateral JSN, Kellgren & Lawrence grade, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain, function, stiffness and the Get up and Go test.

resultsVitamin D supplementation increased 25-OH-D

conclusionVitamin D supplementation did not slow the rate of JSN or lead to reduced pain, stiffness or functional loss over a 3-year period. On the basis of these findings we consider that vitamin D supplementation has no role in the management of knee OA.

Indexed as

Osteoarthritis, KneeDouble-Blind MethodHumansKnee JointVitamin DVitaminsVitamin DVitaminsKneeOsteoarthritisRandomised placebo-controlled trialVitamin D

Identifiers

PMID27264058
PMCPMC5045720
OpenAlexW2411815920

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.