Trial reportAmerican journal of obstetrics and gynecology2016
Impact on family and parental stress of prenatal vs postnatal repair of myelomeningocele.
Trial report in American journal of obstetrics and gynecology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00060606 (Myelomeningocele Repair Randomized Trial), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Myelomeningocele Repair Randomized Trial
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Myelomeningocele Surgery over the 10 Years Following the MOMS Trial: A Systematic Review of Outcomes in Prenatal versus Postnatal Surgical Repair.Medicina (Kaunas, Lithuania) · 2021Pooled it
- Trial
- Society for Maternal-Fetal Medicine Special Statement: Considerations for management of high-risk pregnancies when abortion care is restricted.Pregnancy (Hoboken, N.J.) · 2026Article
- Quality of life in children with myelomeningocele undergoing intrauterine repair and postnatal surgery.The journal of spinal cord medicine · 2026Article
- Maternal decision-making for patients offered prenatal myelomeningocele repair.Pregnancy (Hoboken, N.J.) · 2026Article
- Family dynamics after diagnosis and surgical treatment of myelomeningocele: using telemedicine as a complementary tool.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Review
- Implementation ofAJOG global reports · 2025Article
- The Intrauterine Treatment of Open Spinal Dysraphism.Deutsches Arzteblatt international · 2025Review
- Patient-reported outcomes measure for patients with cleft palate.Frontiers in public health · 2024Review
- Analysis of long-term family dynamics in mothers who have undergone fetal myelomeningocele surgery using telemedicine: a pilot study.Revista da Associacao Medica Brasileira (1992) · 2024Article
- A new ethical framework to determine acceptable risks in fetal therapy trials.Prenatal diagnosis · 2022Review
- A New Ethical Framework for Assessing the Unique Challenges of Fetal Therapy Trials.The American journal of bioethics : AJOB · 2022Article
- Seeking tirelessly for better health and life conditions for the child with myelomeningocele.Revista latino-americana de enfermagem · 2021Article
- Associations between Infant and Parent Characteristics and Measures of Family Well-Being in Neonates with Seizures: A Cohort Study.The Journal of pediatrics · 2020Observational
- Review on myelomeningocele management and its current status in Saudi Arabia.Neurosciences (Riyadh, Saudi Arabia) · 2019Review
- Parental Distress and Stress in Association with Health-Related Quality of Life in Youth with Spina Bifida: A Longitudinal Study.Journal of developmental and behavioral pediatrics : JDBP · 2018Article
- "We want to do everything": how parents represent their experiences with maternal-fetal surgery online.Journal of perinatology : official journal of the California Perinatal Association · 2018Article
- Advances in the prevention and prenatal treatment of spina bifida.Discoveries (Craiova, Romania)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundThe Management of Myelomeningocele Study was a multicenter, randomized controlled trial that compared prenatal repair with standard postnatal repair for fetal myelomeningocele.
objectiveWe sought to describe the long-term impact on the families of the women who participated and to evaluate how the timing of repair influenced the impact on families and parental stress. STUDY
designRandomized women completed the 24-item Impact on Family Scale and the 36-item Parenting Stress Index Short Form at 12 and 30 months after delivery. A revised 15-item Impact on Family Scale describing overall impact was also computed. Higher scores reflected more negative impacts or greater stress. In addition, we examined Family Support Scale and Family Resource Scale scores along with various neonatal outcomes. Repeated measures analysis was conducted for each scale and subscale.
resultsOf 183 women randomized, 171 women completed the Impact on Family Scale and 172 completed the Parenting Stress Index at both 12 and 30 months. The prenatal surgery group had significantly lower revised 15-item Impact on Family Scale scores as well as familial-social impact subscale scores compared to the postnatal surgery group (P = .02 and .004, respectively). There was no difference in total parental stress between the 2 groups (P = .89) or in any of the Parenting Stress Index Short Form subscales. In addition, walking independently at 30 months and family resources at 12 months were associated with both family impact and parental stress.
conclusionThe overall negative family impact of caring for a child with spina bifida, up to 30 months of age, was significantly lower in the prenatal surgery group compared to the postnatal surgery group. Ambulation status and family resources were predictive of impact on family and parental stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.