ArticleNeuron2016
Synaptic Rectification Controls Nonlinear Spatial Integration of Natural Visual Inputs.
Article in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 110 citations in OpenAlex.
- A standard model for the vertebrate retina.Vision research · 2026Article
- Natural motion statistics unify direction computations.bioRxiv : the preprint server for biology · 2026Article
- An image-computable spatio-chromatic receptive field model of the midget retinal ganglion cell mosaic across the retina.Journal of computational neuroscience · 2026Article
- Spatially local inhibition and synaptic plasticity together enable dynamic, context-dependent integration of parallel sensory pathways.Cell reports · 2026Article
- Spatial Adaptation of Primate Retinal Ganglion Cells Between Artificial and Natural Stimuli.eNeuro · 2026Article
- Distinct system-level computations underlie perceptual variation across the visual field.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Modeling spatial contrast sensitivity in responses of primate retinal ganglion cells to natural movies.PLoS computational biology · 2026Article
- Origin and functional impact of early nonlinearities in primate retina.bioRxiv : the preprint server for biology · 2026Article
- Surround motion modulates the encoding properties of primate retinal ganglion cells.Cell reports · 2026Article
- Distinct System-Level Computations Underlie Perceptual Variation Across the Visual Field.bioRxiv : the preprint server for biology · 2025Article
- Spatially-local inhibition and synaptic plasticity together enable dynamic, context-dependent integration of parallel sensory pathways.bioRxiv : the preprint server for biology · 2025Article
- Asymmetric activation of retinal ON and OFF pathways by AOSLO raster-scanned visual stimuli.Biomedical optics express · 2025Article
- Article
- Cell-type specific repertoire of responses to natural scenes in primate retinal ganglion cells.Frontiers in cellular neuroscience · 2025Article
- Asymmetries in the Architecture of ON and OFF Arbors in ON-OFF Direction-Selective Ganglion Cells.The Journal of comparative neurology · 2025Article
- Regional tuning of photoreceptor adaptation in the primate retina.Nature communications · 2024Article
- Applying Super-Resolution and Tomography Concepts to Identify Receptive Field Subunits in the Retina.PLoS computational biology · 2024Article
- Synaptic Origins of the Complex Receptive Field Structure in Primate Smooth Monostratified Retinal Ganglion Cells.eNeuro · 2024Article
- Diversity of Ganglion Cell Responses to Saccade-Like Image Shifts in the Primate Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Spike desensitisation as a mechanism for high-contrast selectivity in retinal ganglion cells.Frontiers in cellular neuroscience · 2023Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
A central goal in the study of any sensory system is to predict neural responses to complex inputs, especially those encountered during natural stimulation. Nowhere is the transformation from stimulus to response better understood than the vertebrate retina. Nevertheless, descriptions of retinal computation are largely based on stimulation using artificial visual stimuli, and it is unclear how these descriptions map onto the encoding of natural stimuli. We demonstrate that nonlinear spatial integration, a common feature of retinal ganglion cell (RGC) processing, shapes neural responses to natural visual stimuli in primate Off parasol RGCs, whereas On parasol RGCs exhibit surprisingly linear spatial integration. Despite this asymmetry, both cell types show strong nonlinear integration when presented with artificial stimuli. We show that nonlinear integration of natural stimuli is a consequence of rectified excitatory synaptic input and that accounting for nonlinear spatial integration substantially improves models that predict RGC responses to natural images.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.