ArticleAmerican journal of hematology2016
Determinants of resting cerebral blood flow in sickle cell disease.
Article in American journal of hematology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 2 of them syntheses that pooled it.
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Who cites it
69 citing papers in PubMed, 2 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- Profiling cerebrovascular function in migraine: A systematic review and meta-analysis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Pooled it
- Pooled it
- Effect of voxelotor on cerebral perfusion and cerebral oxygen metabolism and cardiac stress in adult patients with sickle cell disease.American journal of hematology · 2025Trial
- Sickle cell microvascular paradox-oxygen supply-demand mismatch.American journal of hematology · 2019Trial
- Trial
- White matter has impaired resting oxygen delivery in sickle cell patients.American journal of hematology · 2019Trial
- Trial
- Cerebral Blood Transit in Sickle Cell Anemia.Journal of magnetic resonance imaging : JMRI · 2026Article
- Cerebral blood flow trajectories in paediatric sickle cell anaemia by age, region, and treatment associations.British journal of haematology · 2026Article
- Elevated cerebral blood flow in distal and intermediate arterial territories in pediatric sickle cell anemia.Frontiers in neuroscience · 2026Article
- Observational
- Assessment of cerebral autoregulation and cerebral perfusion in patients with sickle cell disease using frequency-domain near-infrared spectroscopy.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Cerebral vascular shunting and oxygen metabolism in sickle cell disease.Blood advances · 2025Article
- Cerebral Hemodynamic Responses to Disease-Modifying and Curative Sickle Cell Disease Therapies.Neurology · 2025Article
- Altered cerebral blood flow and functional connectivity in sickle cell disease.Journal of sickle cell disease · 2025Article
- Imputation models and error analysis for phase contrast MR cerebral blood flow measurements in heterogeneous pediatric and adult populations.Frontiers in physiology · 2025Article
- Cerebral Autoregulation: A Target for Improving Neurological Outcomes in Extracorporeal Life Support.Neurocritical care · 2024Review
- Cerebral hemodynamics and oxygen metabolism in patients with milder and severe forms of sickle cell disease and thalassemia.HemaSphere · 2024Article
- VICTR: Venous transit time imaging by changes in TMagnetic resonance in medicine · 2024Article
- Cerebrovascular and cardiovascular autonomic regulation in sickle cell patients with white matter lesions.European journal of neurology · 2024Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Stroke is common in children with sickle cell disease and results from an imbalance in oxygen supply and demand. Cerebral blood flow (CBF) is increased in patients with sickle cell disease to compensate for their anemia, but adequacy of their oxygen delivery has not been systematically demonstrated. This study examined the physiological determinants of CBF in 37 patients with sickle cell disease, 38 ethnicity matched control subjects and 16 patients with anemia of non-sickle origin. Cerebral blood flow was measured using phase contrast MRI of the carotid and vertebral arteries. CBF increased inversely to oxygen content (r(2) = 0.69, P < 0.0001). Brain oxygen delivery, the product of CBF and oxygen content, was normal in all groups. Brain composition, specifically the relative amounts of grey and white matter, was the next strongest CBF predictor, presumably by influencing cerebral metabolic rate. Grey matter/white matter ratio and CBF declined monotonically until the age of 25 in all subjects, consistent with known maturational changes in brain composition. Further CBF reductions were observed with age in subjects older than 35 years of age, likely reflecting microvascular aging. On multivariate regression, CBF was independent of disease state, hemoglobin S, hemoglobin F, reticulocyte count and cell free hemoglobin, suggesting that it is regulated similarly in patients and control subjects. In conclusion, sickle cell disease patients had sufficient oxygen delivery at rest, but accomplish this only by marked increases in their resting CBF, potentially limiting their ability to further augment flow in response to stress. Am. J. Hematol. 91:912-917, 2016. © 2016 Wiley Periodicals, Inc.
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Registered trials
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