ArticleScientific reports2016
Chalcone-based Selective Inhibitors of a C4 Plant Key Enzyme as Novel Potential Herbicides.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 25 citations in OpenAlex.
- Disruption of plant cell division by methoxychalcones and cinnamaldehyde: insights into their herbicidal mode of action.Scientific reports · 2026Article
- Downregulation of chalcone isomerase in Petunia hybrida: profound effects on floral morphology and transcriptional remodeling of the flavonoid biosynthetic pathway.BMC plant biology · 2025Article
- Via Air or Rhizosphere: The Phytotoxicity ofPlants (Basel, Switzerland) · 2025Review
- Assessment of 3-Cyanobenzoic Acid as a Possible Herbicide Candidate: Effects on Maize Growth and Photosynthesis.Plants (Basel, Switzerland) · 2024Article
- Chalcones-Features, Identification Techniques, Attributes, and Application in Agriculture.Molecules (Basel, Switzerland) · 2024Review
- Structure-Activity Relationship Study of Xanthoxyline and Related Small Methyl Ketone Herbicides.ACS omega · 2022Article
- A new quinolinone-chalcone hybrid with potential antibacterial and herbicidal properties using in silico approaches.Journal of molecular modeling · 2022Article
- Herbicidal Activity of Flavokawains and RelatedACS omega · 2019Article
- EfficientFrontiers in plant science · 2019Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Weeds are a challenge for global food production due to their rapidly evolving resistance against herbicides. We have identified chalcones as selective inhibitors of phosphoenolpyruvate carboxylase (PEPC), a key enzyme for carbon fixation and biomass increase in the C4 photosynthetic pathway of many of the world's most damaging weeds. In contrast, many of the most important crop plants use C3 photosynthesis. Here, we show that 2',3',4',3,4-Pentahydroxychalcone (IC50 = 600 nM) and 2',3',4'-Trihydroxychalcone (IC50 = 4.2 μM) are potent inhibitors of C4 PEPC but do not affect C3 PEPC at a same concentration range (selectivity factor: 15-45). Binding and modeling studies indicate that the active compounds bind at the same site as malate/aspartate, the natural feedback inhibitors of the C4 pathway. At the whole plant level, both substances showed pronounced growth-inhibitory effects on the C4 weed Amaranthus retroflexus, while there were no measurable effects on oilseed rape, a C3 plant. Growth of selected soil bacteria was not affected by these substances. Our chalcone compounds are the most potent and selective C4 PEPC inhibitors known to date. They offer a novel approach to combat C4 weeds based on a hitherto unexplored mode of allosteric inhibition of a C4 plant key enzyme.
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