ArticleNeurotoxicology and teratology
Early marijuana initiation: The link between prenatal marijuana exposure, early childhood behavior, and negative adult roles.
Article in Neurotoxicology and teratology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Effects of prenatal marijuana exposure on neuropsychological outcomes in children aged 1-11 years: A systematic review.Paediatric and perinatal epidemiology · 2018Pooled it
- Impact of prenatal delta-9-tetrahydrocannabinol exposure on mouse brain development: a fetal-to-adulthood magnetic resonance imaging study.Molecular psychiatry · 2026Article
- Cannabis and Pregnancy: A Review.Obstetrical & gynecological survey · 2023Review
- The effect of the COVID-19 pandemic on substance use patterns and physiological dysregulation in pregnant and postpartum women.Alcohol, clinical & experimental research · 2023Article
- Cannabis use during pregnancy and its effect on the fetus, newborn and later childhood: A systematic review.European journal of midwifery · 2023Review
- In-utero cannabis exposure and long-term psychiatric and neurodevelopmental outcomes: The limitations of existing literature and recommendations for future research.Birth defects research · 2022Review
- The effects of prenatal nicotine and THC E-cigarette exposure on motor development in rats.Psychopharmacology · 2022Article
- Long-term effects of prenatal cannabis exposure: Pathways to adolescent and adult outcomes.Pharmacology, biochemistry, and behavior · 2022Review
- Review
- Receptiveness to participating in cannabis research in pregnancy: a survey study at The Ottawa Hospital.F1000Research · 2021Article
- Cannabis and the developing brain challenge risk perception.The Journal of clinical investigation · 2020Review
- Review
- Cannabis use during pregnancy and postpartum.Canadian family physician Medecin de famille canadien · 2020Review
- Detection ofClinical mass spectrometry (Del Mar, Calif.) · 2019Article
- Cannabis use during pregnancy: Pharmacokinetics and effects on child development.Pharmacology & therapeutics · 2018Review
- Lower-Risk Cannabis Use Guidelines: A Comprehensive Update of Evidence and Recommendations.American journal of public health · 2017Review
- Residential Mobility, Transience, Depression, and Marijuana Use Initiation Among Adolescents and Young Adults.Substance abuse : research and treatment · 2017Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
We investigated the associations among gestational factors including prenatal marijuana exposure (PME), child behavior at age 3, early age of onset of marijuana use (EAOM, <15years), and adult roles at 22years. Participants were drawn from the Maternal Health Practices and Child Development (MHPCD) Project, a longitudinal study of prenatal substance exposure in offspring who have been studied for over 22years since the prenatal phase. Data from the prenatal, birth, 3-, and 22-year phases (N=608) were used in the present study. Age of onset of offspring substance use was determined based on data from the 14-, 16-, and 22-year phases. The subjects were of lower socioeconomic status, 43% were Caucasian and the remaining were African-American, and 48% were males. Early childhood behavior was significantly (p<0.05) related to EAOM after controlling for PME, birth and childhood environmental risk factors, and Conduct Disorder. EAOM was significantly associated with negative adult roles including increased risk of being arrested (p<0.001), lower educational attainment (p<0.001), having a child without being married (p<0.05), and unemployment at 22years (p<0.001). The correlations between PME and negative adult roles and between early childhood behavior and negative adult roles were also statistically significant. Pathway analysis demonstrated that EAOM significantly mediated the associations between PME and fulfillment of adult roles and between early childhood behavior and adult roles. There are a number of intervention points that could be targeted that would have a long-term impact on lowering the probability of EAOM and less success in adult roles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.