Evidence map›Paper›PMID 27262708›Full record

ReviewCurrent treatment options in oncology2016

Management of High-Risk Squamous Cell Carcinoma of the Skin.

Teresa Fu, Sumaira Z Aasi, S Tyler Hollmig

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current treatment options in oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. A Clinical Trial Using Attrition Combined with 5-Aminolevulinic Acids Based Photodynamic Therapy in Treating Squamous Cell Carcinoma.Medical science monitor : international medical journal of experimental and clinical research · 2017
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  16. Molecular Profile of Advanced Cutaneous Squamous Cell Carcinoma.The Journal of clinical and aesthetic dermatology · 2021
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  17. When is a surgical multidisciplinary approach required in the management of head and neck non-melanoma skin cancer and in advanced head and neck pathologies involving skin?Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Teresa FuStanford University Medical Center Department of Dermatology, 450 Broadway, Pavilion C, 2nd Floor, MD-5334, Redwood City, CA, 94063, USA.
Sumaira Z AasiStanford University Medical Center Department of Dermatology, 450 Broadway, Pavilion C, 2nd Floor, MD-5334, Redwood City, CA, 94063, USA.
S Tyler HollmigStanford University Medical Center Department of Dermatology, 450 Broadway, Pavilion C, 2nd Floor, MD-5334, Redwood City, CA, 94063, USA. shollm@stanford.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

opinion statementNon-melanoma skin cancer (NMSC) is the most common malignancy in the USA, with cutaneous squamous cell carcinomas (cSCCs) constituting approximately 20 % of all NMSC. While cSCCs typically behave in an indolent fashion and can be cured with local destructive or surgical methods, a small subset metastasizes and induces significant morbidity and mortality. Identifying and aggressively treating these "high-risk" cSCCs (HRcSCCs) is thus paramount. Recent improvements in staging cSCCs appear to offer better risk stratification than earlier staging criteria. Radiologic imaging and sentinel lymph node biopsy may be beneficial in certain cases of HRcSCC, although more studies are needed before these techniques should be uniformly incorporated into management. Surgery with complete margin control, such as that offered by the Mohs micrographic technique, represents the first-line treatment for these tumors. Radiation therapy is likely most beneficial in the adjuvant setting. Chemotherapy is typically best reserved for patients with metastatic or locally advance disease that is not controllable with surgical and/or radiation therapies. Newer targeted treatments, such as EGFR inhibitors and immunotherapies may offer greater efficacy in these settings, although further evaluation is needed.

Indexed as

AnimalsBiopsyCarcinoma, Squamous CellCombined Modality TherapyDiagnostic ImagingDisease ManagementFollow-Up StudiesHumansNeoplasm GradingNeoplasm StagingSkin NeoplasmsTreatment OutcomeChemotherapyCutaneous squamous cell carcinomaEvaluationHigh-risk squamous cell carcinomaImagingImmunotherapyManagementMohs micrographic surgerySentinel lymph node biopsySurgeryTargeted therapyTreatmentWorkup

Identifiers

PMID27262708

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.