ArticleCancer causes & control : CCC2016
Dietary inflammatory index and ovarian cancer risk in a large Italian case-control study.
Article in Cancer causes & control : CCC, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 5 of them syntheses that pooled it.
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36 citing papers in PubMed, 5 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Dietary inflammatory index and risk of gynecological cancers: a systematic review and meta-analysis of observational studies.Journal of gynecologic oncology · 2019Pooled it
- Dietary Inflammatory Index and Site-Specific Cancer Risk: A Systematic Review and Dose-Response Meta-Analysis.Advances in nutrition (Bethesda, Md.) · 2018Pooled it
- Pooled it
- Meta-analysis of the association between dietary inflammatory index (DII) and cancer outcomes.International journal of cancer · 2017Pooled it
- Pooled it
- Global epidemiology of ovarian cancer: patterns, trends, and risk factors.Cancer biology & medicine · 2026Review
- Integrative Oncology for Biochemical Recurrence of Epithelial Ovarian Cancer.Current oncology reports · 2026Review
- Association of dietary inflammatory index and Chinese healthy eating index with abdominal obesity in kidney transplant recipients.Asia Pacific journal of clinical nutrition · 2026Article
- The association between the dietary inflammatory index and multiple myeloma: a case-control study.Scientific reports · 2025Article
- Dietary Inflammatory Index and Head and Neck Cancer: A Multicenter Case-Control Study in Iran.Journal of research in health sciences · 2024Article
- Dietary inflammatory index is associated with Vitamin D in CKD patients.International urology and nephrology · 2024Article
- Diabetes risk reduction diet and ovarian cancer risk: an Italian case-control study.Cancer causes & control : CCC · 2023Article
- Prevention of Epithelial Ovarian Cancer.Cold Spring Harbor perspectives in medicine · 2023Review
- Integrative Medicine for Ovarian Cancer.Current oncology reports · 2023Review
- Changes in Dietary Inflammatory Index Score over Time and Cancer Development in Rural Post-Menopausal Women.Antioxidants (Basel, Switzerland) · 2023Article
- Endometriosis Stem Cells as a Possible Main Target for Carcinogenesis of Endometriosis-Associated Ovarian Cancer (EAOC).Cancers · 2022Review
- Role of dietary patterns and acculturation in cancer risk and mortality among postmenopausal Hispanic women: results from the Women's Health Initiative (WHI).Zeitschrift fur Gesundheitswissenschaften = Journal of public health · 2022Article
- Dietary inflammatory index and odds of breast cancer: A case-control study.Food science & nutrition · 2021Article
- Pro-inflammatory diet is associated with a high number of cardiovascular events and ultra-processed foods consumption in patients in secondary care.Public health nutrition · 2021Article
- Nutrition in Gynecological Diseases: Current Perspectives.Nutrients · 2021Review
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundWhile inflammation has been shown to play an important etiologic role in ovarian carcinogenesis, little is known about the association between inflammatory properties of diet and ovarian cancer risk.
methodsWe explored the association between the dietary inflammatory index (DII) and ovarian cancer risk in a multicentric Italian case-control study conducted between 1992 and 1999. Cases were 1,031 women with incident, histologically confirmed ovarian cancer from four areas in Italy. Controls were 2,411 women admitted to the same network of hospitals as the cases for acute, non-malignant and non-gynecological conditions, unrelated to hormonal or digestive-tract diseases or committed to long-term modifications of diet. DII scores were computed based on 31 nutrients and food items assessed using a reproducible and validated 78-item food frequency questionnaire. Odds ratios (ORs) were estimated through logistic regression models adjusting for age, total energy intake and other recognized confounding factors.
resultsSubjects in the highest quartile of DII scores (i.e., with the most pro-inflammatory diets) had a higher risk of ovarian cancer compared to subjects in the lowest quartile (i.e., with an anti-inflammatory diet) (ORQuartile4vs1 1.47, 95% confidence interval, CI, 1.07, 2.01; p trend = 0.009). When analyses were carried out using continuous DII, a significant positive association with ovarian cancer was observed: the OR for one-unit increment in DII score (corresponding to approximately 8 % of its range in the current study, +6.0 to -6.20) was 1.08 (95% CI 1.02, 1.14).
conclusionA pro-inflammatory diet as indicated by higher DII scores is associated with increased ovarian cancer risk.
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