Evidence map›Paper›PMID 27261824›Full record

ReviewCardiac electrophysiology clinics2016

Adenosine Triphosphate-Sensitive Potassium Currents in Heart Disease and Cardioprotection.

Colin G Nichols

Open access · greenAbstract readReview
In one paragraph

Review in Cardiac electrophysiology clinics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 49 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Dynamic duo: Kir6 and SUR in KChannels (Austin, Tex.) · 2024
    Review
  8. Article
  9. KArhiv za farmaciju · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. KScientific reports · 2022
    Article
  16. Biological computation: hearts and flytraps.Journal of biological physics · 2022
    Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Colin G NicholsDepartment of Cell Biology and Physiology, Center for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA. Electronic address: cnichols@wustl.edu.
Washington University in St. Louis · US

Funding

ATP-SENSITIVE POTASSIUM CHANNELS IN THE HEARTR01HL045742 · NHLBI · WASHINGTON UNIVERSITY · PI NICHOLS, COLIN G · 1991 to 2016
$3.6M
SUR1 (ABCC8) AND ATRIAL KATP CHANNELSR01HL095010 · NHLBI · WASHINGTON UNIVERSITY · PI NICHOLS, COLIN G · 2009 to 2017
$3.4M
NHLBI NIH HHS R01 HL045742NHLBI NIH HHS R01 HL095010
6 · The paper itself

Abstract

The subunit makeup of the family of adenosine triphosphate-sensitive potassium channel (KATP) channels is more complex and labile than thought. The growing association of Kir6.1 and SUR2 variants with specific cardiovascular electrical and contractile derangements and the clear association with Cantu syndrome establish the importance of appropriate activity in normal function of the heart and vasculature. Further studies of such patients will reveal new mutations in KATP subunits and perhaps in proteins that regulate KATP synthesis, trafficking, or location, all of which may ultimately benefit therapeutically from the unique pharmacology of KATP channels.

Indexed as

Heart DiseasesKATP ChannelsAnimalsCardiomegalyHumansHypertrichosisMiceMice, KnockoutOsteochondrodysplasiasPotassium Channel BlockersKATP ChannelsPotassium Channel BlockersArrhythmiaCantuEdemaKir6.1Kir6.2SUR2Vasodilation

Identifiers

PMID27261824
PMCPMC4894346
OpenAlexW2298101252

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.