ArticleProtein science : a publication of the Protein Society2016
On methylene-bridged cysteine and lysine residues in proteins.
Article in Protein science : a publication of the Protein Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Revealing arginine-cysteine and glycine-cysteine NOS linkages by a systematic re-evaluation of protein structures.Communications chemistry · 2025Article
- Structural Features ofToxins · 2022Article
- Recognizing lysine-cysteine crosslinks in proteins.Protein science : a publication of the Protein Society · 2021Article
- Article
- The Structural Biology of Septins and Their Filaments: An Update.Frontiers in cell and developmental biology · 2021Review
- High-resolution crystal structures of the botulinum neurotoxin binding domains from subtypes A5 and A6.FEBS open bio · 2020Article
- Comment on Wang's paper on the covalent Cys-X-Lys bridges.Protein science : a publication of the Protein Society · 2019Article
- Crystallographic identification of spontaneous oxidation intermediates and products of protein sulfhydryl groups.Protein science : a publication of the Protein Society · 2019Article
- Structure and conformational plasticity of the U6 small nuclear ribonucleoprotein core.Acta crystallographica. Section D, Structural biology · 2017Article
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Authors and funding
2 authors.
Funding
Abstract
Cysteine residues ubiquitously stabilize tertiary and quaternary protein structure by formation of disulfide bridges. Here we investigate another linking interaction that involves sulfhydryl groups of cysteines, namely intra- and intermolecular methylene-bridges between cysteine and lysine residues. A number of crystal structures possessing such a linkage were identified in the Protein Data Bank. Inspection of the electron density maps and re-refinement of the nominated structures unequivocally confirmed the presence of Lys-CH2 -Cys bonds in several cases.
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