Evidence map›Paper›PMID 27261330›Full record

ArticleAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2016

Serum Magnesium Levels and Hospitalization and Mortality in Incident Peritoneal Dialysis Patients: A Cohort Study.

Xiao Yang, Melissa Soohoo, Elani Streja, Matthew B Rivara, Yoshitsugu Obi, Scott V Adams, Kamyar Kalantar-Zadeh, Rajnish Mehrotra

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Xiao YangDepartment of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Melissa SoohooUniversity of California Irvine, Orange, CA.
Elani StrejaUniversity of California Irvine, Orange, CA.
Matthew B RivaraKidney Research Institute and Harborview Medical Center, Division of Nephrology, University of Washington, Seattle, WA.
Yoshitsugu ObiUniversity of California Irvine, Orange, CA.
Scott V AdamsKidney Research Institute and Harborview Medical Center, Division of Nephrology, University of Washington, Seattle, WA.
Kamyar Kalantar-ZadehUniversity of California Irvine, Orange, CA.
Rajnish MehrotraKidney Research Institute and Harborview Medical Center, Division of Nephrology, University of Washington, Seattle, WA. Electronic address: rmehrotr@uw.edu.
University of California, Irvine · USHarborview Medical Center · USThe First Affiliated Hospital, Sun Yat-sen University · CNUniversity of Washington · US

Funding

Comparative Effectiveness of Dialysis ModalitiesR01DK095668 · NIDDK · UNIVERSITY OF WASHINGTON · PI KALANTAR-ZADEH, KAMYAR, MEHROTRA, RAJNISH · 2012 to 2014
$1.0M
NIDDK NIH HHS R01 DK095668
6 · The paper itself

Abstract

backgroundPrior studies have shown the association of low serum magnesium levels with adverse health outcomes in patients undergoing hemodialysis. There is a paucity of such studies in patients undergoing peritoneal dialysis (PD). STUDY

designCohort study. SETTING &

participants10,692 patients treated with PD from January 1, 2007, through December 31, 2011, in facilities operated by a single large dialysis organization in the United States. PREDICTOR: Baseline serum magnesium levels, examined as 5 categories (<1.8, 1.8-<2.0, 2.0-<2.2 [reference], 2.2-<2.4, and ≥2.4mg/dL). OUTCOMES: Time to first hospitalization and time to death using competing-risks regression models.

resultsThe distribution of baseline serum magnesium levels in the cohort was <1.8mg/dL, 1,928 (18%); 1.8 to <2.0mg/dL, 2,204 (21%); 2.0 to <2.2mg/dL, 2,765 (26%); 2.2 to <2.4mg/dL, 1,765 (16%); and ≥2.4mg/dL, 2,030 (19%). Of 10,692 patients, 6,465 (60%) were hospitalized at least once and 1,392 (13%) died during follow-up (median, 13; IQR, 7-23 months). Baseline serum magnesium level < 1.8mg/dL was associated with higher risk for hospitalization and all-cause mortality after adjustment for demographic and clinical characteristics (adjusted HRs of 1.23 [95% CI, 1.14-1.33] and 1.21 [95% CI, 1.03-1.42], respectively). The higher risk for hospitalization persisted upon adjustment for laboratory variables, whereas that for all-cause mortality was attenuated to a nonsignificant level. The greatest risk for hospitalization was in patients with low serum albumin levels (<3.5g/dL; P for interaction < 0.001). LIMITATIONS: Possibility of residual confounding by unmeasured variables cannot be excluded.

conclusionsLower serum magnesium levels may be associated with higher risk for hospitalization in incident PD patients, particularly those with hypoalbuminemia. Additional studies are needed to confirm these findings and investigate whether correction of hypomagnesemia reduces these risks.

Indexed as

HospitalizationAgedCohort StudiesFemaleHumansKidney Failure, ChronicMagnesiumMalePeritoneal DialysisMagnesiumall-cause mortalityend-stage renal disease (ESRD)hospitalizationhypomagnesemiaincident PD patientsMagnesiumperitoneal dialysis (PD)

Identifiers

PMID27261330
PMCPMC5035573
OpenAlexW2410490700

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.