Evidence map›Paper›PMID 27261275›Full record

ReviewNutrition reviews2016

Chemopreventive properties of 3,3'-diindolylmethane in breast cancer: evidence from experimental and human studies.

Cynthia A Thomson, Emily Ho, Meghan B Strom

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrition reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 105 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Cynthia A ThomsonCynthia A. Thomson is with the Mel & Enid Zuckerman College of Public Health, the University of Arizona Cancer Center, and the Department of Nutritional Sciences, University of Arizona, Tucson, Arizona, USA. Emily Ho is with the Moore Family Center for Whole Grain Foods, Nutrition and Preventive Health, College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon, and the Linus Pauling Institute, Oregon State University, Corvallis, Oregon, USA. Meghan B. Strom is with the Department of Nutritional Sciences, University of Arizona, Tucson, Arizona, USA. cthomson@email.arizona.edu.
Emily HoCynthia A. Thomson is with the Mel & Enid Zuckerman College of Public Health, the University of Arizona Cancer Center, and the Department of Nutritional Sciences, University of Arizona, Tucson, Arizona, USA. Emily Ho is with the Moore Family Center for Whole Grain Foods, Nutrition and Preventive Health, College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon, and the Linus Pauling Institute, Oregon State University, Corvallis, Oregon, USA. Meghan B. Strom is with the Department of Nutritional Sciences, University of Arizona, Tucson, Arizona, USA.
Meghan B StromCynthia A. Thomson is with the Mel & Enid Zuckerman College of Public Health, the University of Arizona Cancer Center, and the Department of Nutritional Sciences, University of Arizona, Tucson, Arizona, USA. Emily Ho is with the Moore Family Center for Whole Grain Foods, Nutrition and Preventive Health, College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon, and the Linus Pauling Institute, Oregon State University, Corvallis, Oregon, USA. Meghan B. Strom is with the Department of Nutritional Sciences, University of Arizona, Tucson, Arizona, USA.
Oregon State University · US

Funding

VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Dan Theodorescu · 1985 to 2026
$110.2M
Evaluation of Di-indolylmethane supplementation to modulate tamoxifen efficacy inR01CA149417 · NCI · UNIVERSITY OF ARIZONA · PI THOMSON, CYNTHIA A. · 2010 to 2014
$2.5M
NCI NIH HHS P30 CA023074NCI NIH HHS R01 CA149417
6 · The paper itself

Abstract

Diet is a modifiable factor associated with the risk of several cancers, with convincing evidence showing a link between diet and breast cancer. The role of bioactive compounds of food origin, including those found in cruciferous vegetables, is an active area of research in cancer chemoprevention. This review focuses on 3,3'-diindolylmethane (DIM), the major bioactive indole in crucifers. Research of the cancer-preventive activity of DIM has yielded basic mechanistic, animal, and human trial data. Further, this body of evidence is largely supported by observational studies. Bioactive DIM has demonstrated chemopreventive activity in all stages of breast cancer carcinogenesis. This review describes current evidence related to the metabolism and mechanisms of DIM involved in the prevention of breast cancer. Importantly, this review also focuses on current evidence from human observational and intervention trials that have contributed to a greater understanding of exposure estimates that will inform recommendations for DIM intake.

Indexed as

Anticarcinogenic AgentsAnimalsBrassicaceaeBreast NeoplasmsCell Line, TumorDietFemaleHumansIndolesVegetables3,3'-diindolylmethaneAnticarcinogenic AgentsindoleIndoles3-3′-diindolylmethanebreast cancer chemopreventionglucosinolates.

Identifiers

PMID27261275
PMCPMC5059820
OpenAlexW2417100361

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.