ReviewNutrition reviews2016
The placenta: the forgotten essential organ of iron transport.
Review in Nutrition reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 101 citations in OpenAlex.
- Feasibility Study ofNutrients · 2023Trial
- Maternal Overweight and Obesity during Pregnancy Are Associated with Neonatal, but Not Maternal, Hepcidin Concentrations.The Journal of nutrition · 2021Trial
- Newborn micronutrient status biomarkers in a cluster-randomized trial of antenatal multiple micronutrient compared with iron folic acid supplementation in rural Bangladesh.The American journal of clinical nutrition · 2020Trial
- Screening umbilical cord blood for congenital Iron deficiency.Blood cells, molecules & diseases · 2019Trial
- Iron Overload: Pathophysiology, Diagnosis and Monitoring.International journal of laboratory hematology · 2026Review
- Placental iron utilisation in fetal growth restriction: alterations in mitochondrial haem synthesis and iron-sulphur cluster assembly pathways.The Journal of physiology · 2026Article
- Article
- Mechanism and regulation of iron absorption throughout the life cycle.Journal of advanced research · 2025Review
- Article
- Maternal Ferrous Sucrose Supplementation Improves Reproductive Performance of Sows and Hepatic Iron Stores of Neonatal Piglets.Animals : an open access journal from MDPI · 2025Article
- Article
- Comparison of Molecular Potential for Iron Transfer across the Placenta in Domestic Pigs with Varied Litter Sizes and Wild Boars.International journal of molecular sciences · 2024Article
- Effects of Maternal Dietary Enteromorpha prolifera Polysaccharide Iron Supplement on Mineral Elements and Iron Level of Neonatal Piglets.Biological trace element research · 2024Article
- Gene expression of iron transporters, markers of vascularization and structural integrity in placenta of mothers with and without anemia.Molecular biology reports · 2024Article
- Iron Supplementation of Pregnant Sows to Prevent Iron Deficiency Anemia in Piglets: A Procedure of Questionable Effectiveness.International journal of molecular sciences · 2024Review
- Molecular insights into placental iron transfer mechanisms and maternofetal regulation.Archives of gynecology and obstetrics · 2024Review
- Meconium Transferrin and Ferritin as Markers of Homeostasis in the Developing Fetus.International journal of molecular sciences · 2023Article
- The Ferritin, Hepcidin and Cytokines Link in the Diagnoses of Iron Deficiency Anaemia during Pregnancy: A Review.International journal of molecular sciences · 2023Review
- Iron Homeostasis During Pregnancy: Maternal, Placental, and Fetal Regulatory Mechanisms.Annual review of nutrition · 2023Review
- The Role of Ferroptosis in Placental-Related Diseases.Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Optimal iron nutrition in utero is essential for development of the fetus and helps establish birth iron stores adequate to sustain growth in early infancy. In species with hemochorial placentas, such as humans and rodents, iron in the maternal circulation is transferred to the fetus by directly contacting placental syncytiotrophoblasts. Early kinetic studies provided valuable data on the initial uptake of maternal transferrin, an iron-binding protein, by the placenta. However, the remaining steps of iron trafficking across syncytiotrophoblasts and through the fetal endothelium into the fetal blood remain poorly characterized. Over the last 20 years, identification of transmembrane iron transporters and the iron regulatory hormone hepcidin has greatly expanded the knowledge of cellular iron transport and its regulation by systemic iron status. In addition, emerging human and animal data demonstrating comprised fetal iron stores in severe maternal iron deficiency challenge the classic dogma of exclusive fetal control over the transfer process and indicate that maternal and local signals may play a role in regulating this process. This review compiles current data on the kinetic, molecular, and regulatory aspects of placental iron transport and considers new questions and knowledge gaps raised by these advances.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.