Evidence map›Paper›PMID 27261273›Full record

ReviewNutrition reviews2016

Chromium supplements for glycemic control in type 2 diabetes: limited evidence of effectiveness.

Rebecca B Costello, Johanna T Dwyer, Regan L Bailey

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrition reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 82 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Rebecca B CostelloR.B. Costello, J.T. Dwyer, and R.L. Bailey are with the Office of Dietary Supplements, National Institutes of Health, Bethesda, Maryland, USA. J.T. Dwyer is with the School of Medicine and Friedman School of Nutrition Science and Policy, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA. R.L. Bailey is with the Department of Nutrition Science, Purdue University, West Lafayette, Indiana, USA. costellb@od.nih.gov.
Johanna T DwyerR.B. Costello, J.T. Dwyer, and R.L. Bailey are with the Office of Dietary Supplements, National Institutes of Health, Bethesda, Maryland, USA. J.T. Dwyer is with the School of Medicine and Friedman School of Nutrition Science and Policy, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA. R.L. Bailey is with the Department of Nutrition Science, Purdue University, West Lafayette, Indiana, USA.
Regan L BaileyR.B. Costello, J.T. Dwyer, and R.L. Bailey are with the Office of Dietary Supplements, National Institutes of Health, Bethesda, Maryland, USA. J.T. Dwyer is with the School of Medicine and Friedman School of Nutrition Science and Policy, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA. R.L. Bailey is with the Department of Nutrition Science, Purdue University, West Lafayette, Indiana, USA.
Tufts University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Some adults with type 2 diabetes mellitus (T2DM) believe that chromium-containing supplements will help control their disease, but the evidence is mixed. This narrative review examines the efficacy of chromium supplements for improving glycemic control as measured by decreases in fasting plasma glucose (FPG) or hemoglobin A1c (HbA1c). Using systematic search criteria, 20 randomized controlled trials of chromium supplementation in T2DM patients were identified. Clinically meaningful treatment goals were defined as an FPG of ≤7.2 mmol/dL, a decline in HbA1c to ≤7%, or a decrease of ≥0.5% in HbA1c. In only a few randomized controlled trials did FPG (5 of 20), HbA1c (3 of 14), or both (1 of 14) reach the treatment goals with chromium supplementation. HbA1c declined by ≥0.5% in 5 of 14 studies. On the basis of the low strength of existing evidence, chromium supplements have limited effectiveness, and there is little rationale to recommend their use for glycemic control in patients with existing T2DM. Future meta-analyses should include only high-quality studies with similar forms of chromium and comparable inclusion/exclusion criteria to provide scientifically sound recommendations for clinicians.

Indexed as

Blood GlucoseChromiumDiabetes Mellitus, Type 2Dietary SupplementsFastingGlycated HemoglobinHumansRandomized Controlled Trials as TopicBlood GlucoseChromiumGlycated Hemoglobinchromiumfasting plasma glucosehemoglobin A1ctype 2 diabetes mellitus.

Identifiers

PMID27261273
PMCPMC5009459
OpenAlexW2416752667

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.