ArticleActa physiologica (Oxford, England)2016
Shear stress-induced angiogenesis in mouse muscle is independent of the vasodilator mechanism and quickly reversible.
Article in Acta physiologica (Oxford, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Kidney organoid vascularization: current advancements in the field.Regenerative therapy · 2026Article
- Centenarians-the way to healthy vascular ageing and longevity: a review from VascAgeNet.GeroScience · 2025Review
- Biomaterial-based mechanical regulation facilitates scarless wound healing with functional skin appendage regeneration.Military Medical Research · 2024Review
- Exercise-induced skeletal muscle angiogenesis: impact of age, sex, angiocrines and cellular mediators.European journal of applied physiology · 2023Review
- Mechanical regulation of the early stages of angiogenesis.Journal of the Royal Society, Interface · 2022Review
- Distinct structural and functional angiogenic responses are induced by different mechanical stimuli.Microcirculation (New York, N.Y. : 1994) · 2021Article
- Influence of hypoxic stimulation on angiogenesis and satellite cells in mouse skeletal muscle.PloS one · 2018Article
- The superoxide dismutase mimetic tempol does not alleviate glucocorticoid-mediated rarefaction of rat skeletal muscle capillaries.Physiological reports · 2017Article
- A differential role for nitric oxide in two forms of physiological angiogenesis in mouse.The Journal of physiology · 2006Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
aimIs modulation of skeletal muscle capillary supply by altering blood flow due to a presumptive shear stress response per se, or dependent on the vasodilator mechanism?
methodsThe response to four different vasodilators, and cotreatment with blockers of NO and prostaglandin synthesis, was compared. Femoral artery blood flow was correlated with capillary-to-fibre ratio (C:F) and protein levels of putative angiogenic compounds.
resultsAll vasodilators induced a similar increase in blood flow after 14 days, with a similar effect on C:F (1.62 ± 0.05, 1.60 ± 0.01, 1.57 ± 0.06, 1.57 ± 0.07, respectively, all P < 0.05 vs. control 1.20 ± 0.01). Concomitant inhibitors revealed differential effects on blood flow and angiogenesis, demonstrating that a similar response may have different signalling origins. The time course of this response with the most commonly used vasodilator, prazosin, showed that blood flow increased from 0.40 mL min
conclusionHyperaemia-induced angiogenesis, likely in response to elevated shear stress, is independent of the vasodilator involved, with a rapid induction and quick regression following the stimulus withdrawal.
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