ReviewJournal of immunology (Baltimore, Md. : 1950)2016
What Happens in the Thymus Does Not Stay in the Thymus: How T Cells Recycle the CD4+-CD8+ Lineage Commitment Transcriptional Circuitry To Control Their Function.
Review in Journal of immunology (Baltimore, Md. : 1950), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 28 citations in OpenAlex.
- Perivascular Tertiary Lymphoid Structures in Autoimmune Disease.Immunological reviews · 2025Review
- Zfp281 and Zfp148 control CD4Science immunology · 2023Article
- Hic et Runx: new insights into T cell tissue residency.Trends in immunology · 2022Article
- NuRD complex recruitment to Thpok mediates CD4Science immunology · 2022Article
- Tumor-induced double positive T cells display distinct lineage commitment mechanisms and functions.The Journal of experimental medicine · 2022Article
- Human CD4 T Cells From Thymus and Cord Blood Are Convertible Into CD8 T Cells by IL-4.Frontiers in immunology · 2022Article
- TET proteins regulate T cell and iNKT cell lineage specification in a TET2 catalytic dependent manner.Frontiers in immunology · 2022Article
- Review: Development of SARS-CoV-2 immuno-enhanced COVID-19 vaccines with nano-platform.Nano research · 2022Review
- Effect of radiotherapy on T cell and PD-1 / PD-L1 blocking therapy in tumor microenvironment.Human vaccines & immunotherapeutics · 2021Review
- Complex Interplay Between MAZR and Runx3 Regulates the Generation of Cytotoxic T Lymphocyte and Memory T Cells.Frontiers in immunology · 2021Article
- CD4Frontiers in immunology · 2020Article
- Beneficial and Deleterious Effects of Female Sex Hormones, Oral Contraceptives, and Phytoestrogens by Immunomodulation on the Liver.International journal of molecular sciences · 2019Review
- A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation.Immunity · 2019Article
- HLA class II-Restricted CD8+ T cells in HIV-1 Virus Controllers.Scientific reports · 2019Article
- Systemic response to rupture of intracranial aneurysms involves expression of specific gene isoforms.Journal of translational medicine · 2019Article
- Cutting Edge: The Histone Methyltransferase G9a Is Required for Silencing of Helper T Lineage-Associated Genes in Proliferating CD8 T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Article
- An Immunotherapeutic CD137 Agonist Releases Eomesodermin from ThPOK Repression in CD4 T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- A STAT3-dependent transcriptional circuitry inhibits cytotoxic gene expression in T cells.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Control of Regulatory T Cell Differentiation by the Transcription Factors Thpok and LRF.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
MHC-restricted CD4(+) and CD8(+) T cells are at the core of most adaptive immune responses. Although these cells carry distinct functions, they arise from a common precursor during thymic differentiation, in a developmental sequence that matches CD4 and CD8 expression and functional potential with MHC restriction. Although the transcriptional control of CD4(+)-CD8(+) lineage choice in the thymus is now better understood, less was known about what maintains the CD4(+) and CD8(+) lineage integrity of mature T cells. In this review, we discuss the mechanisms that establish in the thymus, and maintain in postthymic cells, the separation of these lineages. We focus on recent studies that address the mechanisms of epigenetic control of Cd4 expression and emphasize how maintaining a transcriptional circuitry nucleated around Thpok and Runx proteins, the key architects of CD4(+)-CD8(+) lineage commitment in the thymus, is critical for CD4(+) T cell helper functions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.