Evidence map›Paper›PMID 27260655›Full record

ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2017

A balanced translocation disrupting BCL2L10 and PNLDC1 segregates with affective psychosis.

Christian G Bouwkamp, Anneke J A Kievit, Simone Olgiati, Guido J Breedveld, Michiel Coesmans, Vincenzo Bonifati, Steven A Kushner

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PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. VariantThe New England journal of medicine · 2021
    Article
  4. Review
  5. A balanced translocation disrupting BCL2L10 and PNLDC1 segregates with affective psychosis.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Christian G BouwkampDepartment of Psychiatry, Erasmus University Medical Center, Rotterdam, The Netherlands.
Anneke J A KievitDepartment of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.
Simone OlgiatiDepartment of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.
Guido J BreedveldDepartment of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.
Michiel CoesmansDepartment of Psychiatry, Erasmus University Medical Center, Rotterdam, The Netherlands.
Vincenzo BonifatiDepartment of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.
Steven A KushnerDepartment of Psychiatry, Erasmus University Medical Center, Rotterdam, The Netherlands.
Erasmus MC · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Affective psychoses are a group of severe psychiatric disorders, including schizoaffective disorder and bipolar I disorder, together affecting ∼1% of the population. Despite their high heritability, the molecular genetics and neurobiology of affective psychosis remain largely elusive. Here, we describe the identification of a structural genetic variant segregating with affective psychosis in a family with multiple members suffering from bipolar I disorder or schizoaffective disorder, bipolar type. A balanced translocation involving chromosomes 6 and 15 was detected by karyotyping and fluorescence in-situ hybridization (FISH). Using whole-genome sequencing, we rapidly delineated the translocation breakpoints as corresponding intragenic events disrupting BCL2L10 and PNLDC1. These data warrant further consideration for BCL2L10 and PNLDC1 as novel candidates for affective psychosis. © 2016 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics Published by Wiley Periodicals, Inc.

Indexed as

AdultAffective Disorders, PsychoticBipolar DisorderChromosomes, Human, Pair 15Chromosomes, Human, Pair 6CytogeneticsExoribonucleasesFemaleHumansIn Situ Hybridization, FluorescenceKaryotypingMalePedigreeProto-Oncogene Proteins c-bcl-2Psychotic DisordersSchizophreniaBCL2-like 10 proteinExoribonucleasesProto-Oncogene Proteins c-bcl-2affective psychosisbalanced translocationBCL2L10bipolar disordercytogeneticsPNLDC1schizoaffective disorderwhole-genome sequencing

Identifiers

PMID27260655
PMCPMC5363242
OpenAlexW2416040573

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.