Evidence map›Paper›PMID 27260562›Full record

ArticleTechnology in cancer research & treatment2017

Single-Fraction Spine Stereotactic Body Radiation Therapy for the Treatment of Chordoma.

Edward W Jung, David L Jung, Ehsan H Balagamwala, Lilyana Angelov, John H Suh, Toufik Djemil, Anthony Magnelli, Samuel T Chao

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Technology in cancer research & treatment, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Late recurrence of cervical spine chordoma: illustrative case.Journal of neurosurgery. Case lessons · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Comprehensive Review of Cranial Chordomas Using National Databases in the USA.Clinical oncology (Royal College of Radiologists (Great Britain)) · 2019
    Review
  8. Stereotactic Body Radiation Therapy for Spinal Malignancies.Technology in cancer research & treatment · 2018
    Review
  9. Article
  10. Advances in Radiation Therapy for Primary Bone Malignancies.Technology in cancer research & treatment
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Edward W Jung1 Department of Radiation Oncology, Cleveland Clinic Foundation, Cleveland, OH, USA.
David L Jung2 Case Western Reserve Medical School, Cleveland, OH, USA.
Ehsan H Balagamwala1 Department of Radiation Oncology, Cleveland Clinic Foundation, Cleveland, OH, USA.
Lilyana Angelov3 Department of Neurosurgery, Cleveland Clinic Foundation, Cleveland, OH, USA.
John H Suh1 Department of Radiation Oncology, Cleveland Clinic Foundation, Cleveland, OH, USA.
Toufik Djemil1 Department of Radiation Oncology, Cleveland Clinic Foundation, Cleveland, OH, USA.
Anthony Magnelli1 Department of Radiation Oncology, Cleveland Clinic Foundation, Cleveland, OH, USA.
Samuel T Chao1 Department of Radiation Oncology, Cleveland Clinic Foundation, Cleveland, OH, USA.
Cleveland Clinic · USCase Western Reserve University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeChordoma is a radioresistant tumor that presents a therapeutic challenge with spine involvement, as high doses of radiation are needed for local control while limiting dose to the spinal cord. The purpose of this study is to determine the efficacy and safety of single-fraction spine stereotactic body radiation therapy for the treatment of spine chordoma.

methodsA retrospective review of our institutional database from 2006 to 2013 identified 8 patients (12 cases) with chordoma of the spine who were treated with spine stereotactic body radiation therapy. Surgical resection was performed in 7 of the 12 cases. The treatment volume was defined by the bony vertebral level of the tumor along with soft tissue extension appreciated on magnetic resonance imaging fusion. Medical records and imaging were assessed for pain relief and local control. Treatment toxicity was evaluated using Common Terminology Criteria for Adverse Events version 4.0.

resultsMedian age was 59 years (range, 17-91). Median target volume was 48 cm

conclusionSingle-fraction spine stereotactic body radiation therapy can be safely delivered to treat chordoma of the spine with the potential to improve pain symptoms. Although the early data are suggestive, long-term follow-up with more patients is necessary to determine the efficacy of spine stereotactic body radiation therapy in the treatment of chordoma of the spine.

Indexed as

AdolescentAdultAgedAged, 80 and overChordomaDisease-Free SurvivalFemaleFollow-Up StudiesHumansMaleMiddle AgedRadiosurgerySpinal NeoplasmsSpineTreatment OutcomechordomaradiosurgerySBRTspineSRS

Identifiers

PMID27260562
PMCPMC5616044
OpenAlexW2414411585

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.