Evidence map›Paper›PMID 27260320›Full record

ArticleThe Journal of allergy and clinical immunology2016

Understanding the feasibility and implications of implementing early peanut introduction for prevention of peanut allergy.

Jennifer J Koplin, Rachel L Peters, Shyamali C Dharmage, Lyle Gurrin, Mimi L K Tang, Anne-Louise Ponsonby, Melanie Matheson, Alkis Togias, Gideon Lack, Katrina J Allen and 1 more

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in The Journal of allergy and clinical immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 132 citations in OpenAlex.

  1. Guideline
  2. Trial
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Jug r 1 sensitization in 0- to 35-month-old children with egg, milk, or wheat sensitization.The journal of allergy and clinical immunology. Global · 2023
    Article
  12. Article
  13. Article
  14. Primary Prevention of Allergy - Is It Feasible?Allergy, asthma & immunology research · 2023
    Review
  15. Article
  16. Observational
  17. A pragmatic approach to infant feeding for food allergy prevention.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022
    Article
  18. Article
  19. Dietary exposures and allergy prevention in high-risk infants.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2022
    Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Jennifer J KoplinMurdoch Childrens Research Institute, University of Melbourne Department of Paediatrics and Department of Allergy and Clinical Immunology at the Royal Children's Hospital, Parkville, Australia; School of Population and Global Health, University of Melbourne, Parkville, Australia.
Rachel L PetersMurdoch Childrens Research Institute, University of Melbourne Department of Paediatrics and Department of Allergy and Clinical Immunology at the Royal Children's Hospital, Parkville, Australia.
Shyamali C DharmageSchool of Population and Global Health, University of Melbourne, Parkville, Australia.
Lyle GurrinSchool of Population and Global Health, University of Melbourne, Parkville, Australia.
Mimi L K TangMurdoch Childrens Research Institute, University of Melbourne Department of Paediatrics and Department of Allergy and Clinical Immunology at the Royal Children's Hospital, Parkville, Australia.
Anne-Louise PonsonbyMurdoch Childrens Research Institute, University of Melbourne Department of Paediatrics and Department of Allergy and Clinical Immunology at the Royal Children's Hospital, Parkville, Australia.
Melanie MathesonSchool of Population and Global Health, University of Melbourne, Parkville, Australia.
Alkis TogiasNational Institute of Allergy and Infectious Diseases, Bethesda, Md.
Gideon LackDepartment of Pediatric Allergy, Division of Asthma, Allergy and Lung Biology, King's College London and Guy's and St Thomas' National Health Service Foundation Trust, London, United Kingdom.
Katrina J AllenMurdoch Childrens Research Institute, University of Melbourne Department of Paediatrics and Department of Allergy and Clinical Immunology at the Royal Children's Hospital, Parkville, Australia; School of Inflammation and Repair, University of Manchester, Manchester, United Kingdom. Electronic address: katie.allen@rch.org.au.
HealthNuts study investigators
University of Melbourne · AURoyal Children's Hospital · AUMurdoch Children's Research Institute · AUGuy's and St Thomas' NHS Foundation Trust · GBNational Institute of Allergy and Infectious Diseases · USUniversity of Manchester · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA recent randomized trial (the Learning Early About Peanut Allergy [LEAP] study) provided evidence that earlier dietary peanut introduction reduces peanut allergy prevalence in high-risk infants. However, questions remain as to how to identify and target the "at-risk" population to facilitate timely introduction of peanut.

objectiveWe sought to use population-based infant peanut allergy data to understand feasibility and implications of implementing the LEAP trial intervention.

methodsUsing the HealthNuts study cohort (n = 5276) of 1-year-old infants, we explored the impact of using various criteria to identify infants at high risk of developing peanut allergy, and the implications of skin prick test (SPT) screening before peanut introduction.

resultsScreening all infants with early onset eczema and/or egg allergy could require testing 16% of the population and would still miss 23% of peanut allergy cases; 29% of screened infants would require clinical follow-up because of being SPT-positive. Around 11% of high-risk infants were excluded from the LEAP study because of an SPT wheal size of more than 4 mm to peanut at baseline; data from the HealthNuts study suggest that 80% of these would be peanut allergic on food challenge. There were no life-threatening events among either low- or high-risk infants whose parents chose to introduce peanut at home in the first year of life, or in 150 peanut-allergic infants during hospital-based challenges.

conclusionsBased on this large epidemiological study, a population program aiming to identify and screen all infants at risk of peanut allergy would pose major cost and logistic challenges that need to be carefully considered. Further research might be required to provide data for low-risk infants.

Indexed as

ArachisDietAge FactorsFeasibility StudiesFemaleHumansInfantMalePeanut HypersensitivityRisk FactorsTime Factorsguidelinesinfant feedingPeanut allergypreventionskin prick testspecific IgE

Identifiers

PMID27260320
OpenAlexW2346296575

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.