ArticleHearing research2016
A cool approach to reducing electrode-induced trauma: Localized therapeutic hypothermia conserves residual hearing in cochlear implantation.
Article in Hearing research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Device to Deliver Intra-Operative Therapeutic Hypothermia for Hearing Preservation in Cochlear Implantation
Non-Invasive System to Deliver Therapeutic Hypothermia for Protection Against Noise-Induced Hearing Loss
Mild Therapeutic Hypothermia for Tinnitus Management
Noninvasive Therapeutic Hypothermia for Tinnitus
Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- Physiological limits of localized hypothermia in the human cochlea: The role of vascular heat transport.bioRxiv : the preprint server for biology · 2026Article
- Development and Evaluation of a Novel Transcanal Catheter for Delivery of Hypothermia to the Inner Ear.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2025Article
- Optimizing Factors in Murine Whole-Organ Cochlea Culture.International journal of molecular sciences · 2025Article
- Comparison of actions of ketamine and telazol on cochlear function in a rodent model of noise-induced hearing loss.Brain research · 2025Article
- Cooling the Cochlea: Slowing Down Metabolism May Be a Way of Protecting Hearing from Surgical Trauma.Medicina (Kaunas, Lithuania) · 2023Review
- Effects of Therapeutic Hypothermia on Macrophages in Mouse Cochlea Explants.International journal of molecular sciences · 2023Article
- The protective effect of aspirin-induced temporary threshold shift in an animal model of cisplatin-related ototoxicity.Journal of cancer research and clinical oncology · 2023Article
- Mild therapeutic hypothermia protects against inflammatory and proapoptotic processes in the rat model of cochlear implant trauma.Hearing research · 2023Article
- Targeted therapeutic hypothermia protects against noise induced hearing loss.Frontiers in neuroscience · 2023Article
- The effects of mild hypothermia on the electrode insertion trauma in a murine whole organ cochlea culture.Frontiers in neuroscience · 2023Article
- A reliable and reproducible protocol for sound-evoked vestibular myogenic potentials in rattus norvegicus.Frontiers in integrative neuroscience · 2023Article
- Transcriptional response to mild therapeutic hypothermia in noise-induced cochlear injury.Frontiers in neuroscience · 2023Article
- The Effect of Pluronic-Coated Gold Nanoparticles in Hearing Preservation Following Cochlear Implantation-Pilot Study.Audiology research · 2022Article
- The Otoprotective Effect of Ear Cryotherapy: Systematic Review and Future Perspectives.Audiology research · 2022Review
- Mild Therapeutic Hypothermia and Putative Mechanisms of Hair Cell Survival in the Cochlea.Antioxidants & redox signaling · 2022Article
- Current Concepts and Future Trends in Increasing the Benefits of Cochlear Implantation: A Narrative Review.Medicina (Kaunas, Lithuania) · 2022Review
- Cool OtOprotective Ear Lumen (COOL) Therapy for Cisplatin-induced Hearing Loss.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2021Article
- Heat transfer analysis in an uncoiled model of the cochlea during magnetic cochlear implant surgery.International journal of heat and mass transfer · 2020Article
- Therapeutic hypothermia reduces cortical inflammation associated with utah array implants.Journal of neural engineering · 2020Article
- Measurement of the Intracochlear Hypothermia Distribution Utilizing Tympanic Cavity Hypothermic Rinsing Technique in a Cochlea Hypothermia Model.Frontiers in neurology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe trauma caused during cochlear implant insertion can lead to cell death and a loss of residual hair cells in the cochlea. Various therapeutic approaches have been studied to prevent cochlear implant-induced residual hearing loss with limited success. In the present study, we show the efficacy of mild to moderate therapeutic hypothermia of 4 to 6 °C applied to the cochlea in reducing residual hearing loss associated with the electrode insertion trauma. APPROACH: Rats were randomly distributed in three groups: control contralateral cochleae, normothermic implanted cochleae and hypothermic implanted cochleae. Localized hypothermia was delivered to the middle turn of the cochlea for 20 min before and after implantation using a custom-designed probe perfused with cooled fluorocarbon. Auditory brainstem responses (ABRs) were recorded to assess the hearing function prior to and post-cochlear implantation at various time points up to 30 days. At the conclusion of the trials, inner ears were harvested for histology and cell count. The approach was extended to cadaver temporal bones to study the potential surgical approach and efficacy of our device. In this case, the hypothermia probe was placed next to the round window niche via the facial recess or a myringotomy. MAIN
resultsA significant loss of residual hearing was observed in the normothermic implant group. Comparatively, the residual hearing in the cochleae receiving therapeutic hypothermia was significantly conserved. Histology confirmed a significant loss of outer hair cells in normothermic cochleae receiving the surgical trauma when compared to the hypothermia treated group. In human temporal bones, a controlled and effective cooling of the cochlea was achieved using our approach. SIGNIFICANCE: Collectively, these results suggest that therapeutic hypothermia during cochlear implantation may reduce traumatic effects of electrode insertion and improve conservation of residual hearing.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.