Evidence map›Paper›PMID 27260246›Full record

ArticleUltrasound in medicine & biology2016

Ex Vivo Porcine Arterial and Chorioallantoic Membrane Acoustic Angiography Using Dual-Frequency Intravascular Ultrasound Probes.

K Heath Martin, Brooks D Lindsey, Jianguo Ma, Timothy C Nichols, Xiaoning Jiang, Paul A Dayton

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasound in medicine & biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. High-Frequency, 2-mm-Diameter Forward-Viewing 2-D Array for 3-D Intracoronary Blood Flow Imaging.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2024
    Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Validation of Ultrasound Super-Resolution Imaging of Vasa Vasorum in Rabbit Atherosclerotic Plaques.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2020
    Article
  8. Article
  9. Article
  10. Dual-Frequency Piezoelectric Endoscopic Transducer for Imaging Vascular Invasion in Pancreatic Cancer.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2017
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

K Heath MartinJoint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, North Carolina, USA.
Brooks D LindseyJoint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, North Carolina, USA.
Jianguo MaDepartment of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, North Carolina, USA.
Timothy C NicholsDepartment of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.
Xiaoning JiangDepartment of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, North Carolina, USA.
Paul A DaytonJoint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, North Carolina, USA; Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, North Carolina, USA. Electronic address: padayton@email.unc.edu.
North Carolina State University · USUniversity of North Carolina at Chapel Hill · US

Funding

Dual-frequency intravascular arrays for functional imaging of atherosclerosisR01EB015508 · NIBIB · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI JIANG, XIAONING · 2012 to 2015
$2.0M
NIBIB NIH HHS R01 EB015508
6 · The paper itself

Abstract

The presence of blood vessels within a developing atherosclerotic plaque has been found to be correlated with increased plaque vulnerability and ensuing cardiac events, however, detection of coronary intraplaque neovascularization poses a significant challenge in the clinic. We describe here a new in vivo intravascular ultrasound imaging method using a dual-frequency transducer to visualize contrast flow in microvessels with high specificity. This method uses a specialized transducer capable of exciting contrast agents at a low frequency (5.5 MHz) while detecting their nonlinear superhamonics at a much higher frequency (37 MHz). In vitro evaluation of the approach was performed in a microvascular phantom to produce 3-D renderings of simulated vessel patterns and to determine image quality metrics as a function of depth. Furthermore, we describe the ability of the system to detect microvessels both ex vivo using porcine arteries and in vivo using the chorioallantoic membrane of a developing chicken embryo with optical confirmation. Dual-frequency contrast-specific imaging was able to resolve vessels similar in size to those found in vulnerable atherosclerotic plaques at clinically relevant depths. The results of this study add to the support for further evaluation and translation of contrast-specific imaging in intravascular ultrasound for the detection of vulnerable plaques in atherosclerosis.

Indexed as

AngiographyAnimalsArteriesChick EmbryoChorioallantoic MembraneComputer SimulationContrast MediaImage EnhancementMicrovesselsModels, AnimalModels, BiologicalPhantoms, ImagingSensitivity and SpecificitySwineTransducersUltrasonography, InterventionalContrast MediaAcoustic angiographyAtherosclerosisContrastDual frequencyIntravascular ultrasoundMicrobubbleSuperharmonicUltrasonographyVasa vasorum

Identifiers

PMID27260246
PMCPMC5653969
OpenAlexW2416923881

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.