ArticleEuropean journal of nutrition2017
Zinc supplementation induces CD4
Article in European journal of nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 63 citations in OpenAlex.
- The Zinc-Senescence Axis in Skin Aging and Wound Healing: A Narrative Review.International journal of molecular sciences · 2026Review
- Zinc Supplementation Partially Reconstitutes Impaired Interferon-γ Production in the Elderly.International journal of molecular sciences · 2026Article
- Adjunctive zinc supplementation with methotrexate improves therapeutic outcomes in an animal model of arthritis.Inflammopharmacology · 2025Article
- CaCell death discovery · 2024Article
- Zinc dampens antitumor immunity by promoting Foxp3Frontiers in immunology · 2024Article
- Antioxidant and Immune-Related Implications of Minerals in COVID-19: A Possibility for Disease Prevention and Management.Antioxidants (Basel, Switzerland) · 2023Review
- Zinc in Human Health and Infectious Diseases.Biomolecules · 2022Review
- Possible relationship between poor skin disorders prognosis and serum zinc level: A narrative review.Dermatology reports · 2022Article
- Can iron, zinc, copper and selenium status be a prognostic determinant in COVID-19 patients?Environmental toxicology and pharmacology · 2022Review
- Zinc Supplementation Improved Neuropeptide Y, Nesfatin-1, Leptin, C-reactive protein, and HOMA-IR of Diet-Induced Obese Rats.Biological trace element research · 2022Article
- Short-term zinc supplementation of zinc-deficient seniors counteracts CREMα - mediated IL-2 suppression.Immunity & ageing : I & A · 2022Article
- The effect of Vitamin C and Zn supplementation on the immune system and clinical outcomes in COVID-19 patients.Clinical nutrition open science · 2022Review
- Antiviral and immunological activity of zinc and possible role in COVID-19.The British journal of nutrition · 2022Review
- Review
- Supplementation With Zinc Proteinate Increases the Growth Performance by Reducing the Incidence of Diarrhea and Improving the Immune Function of Dairy Calves During the First Month of Life.Frontiers in veterinary science · 2022Article
- Zinc Modulates the Priming of T Helper 1, T Helper 17, and T Regulatory Cells in Allogeneic and Autologous in vitro Models.Journal of inflammation research · 2022Article
- Possible Benefits of Zinc supplement in CVD and COVID-19 Comorbidity.Journal of infection and public health · 2021Review
- Can Zn Be a Critical Element in COVID-19 Treatment?Biological trace element research · 2021Review
- Diet and Hygiene in Modulating Autoimmunity During the Pandemic Era.Frontiers in immunology · 2021Review
- Potential benefits of combination ofJournal of herbal medicine · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe essential trace element zinc plays a fundamental role in immune function and regulation since its deficiency is associated with autoimmunity, allergies, and transplant rejection. Thus, we investigated the influence of zinc supplementation on the Th1-driven alloreaction in mixed lymphocyte cultures (MLC), on generation of antigen-specific T cells, and analyzed underlying molecular mechanisms.
methodsCell proliferation and pro-inflammatory cytokine production were monitored by [
resultsZinc supplementation on antigen-specific T cells in physiological doses (50 µM) provokes a significant amelioration of cell proliferation and pro-inflammatory cytokine production after reactivation compared to untreated controls. Zinc administration on MLC results in an increased induction and stabilization of CD4
conclusionIn summary, zinc is capable of ameliorating the allogeneic immune reaction by enhancement of antigen-specific iTreg cells due to modulation of essential molecular targets: Foxp3, KLF-10, and IRF-1. Thus, zinc can be seen as an auspicious tool for inducing tolerance in adverse immune reactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.