ArticleJournal of immunology (Baltimore, Md. : 1950)2016
IL-27 Induced by Select Candida spp. via TLR7/NOD2 Signaling and IFN-β Production Inhibits Fungal Clearance.
Article in Journal of immunology (Baltimore, Md. : 1950), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Rethinking the immune recognition of cell walls in human fungal pathogens: Mechanisms, controversies and translational significance.Virulence · 2026Review
- Cytosolic receptors and signaling in antifungal immunity.The EMBO journal · 2025Review
- Adiponectin pathway activation dampens inflammation and enhances alveolar macrophage fungal killing via LC3-associated phagocytosis.PLoS pathogens · 2025Article
- Immunomodulatory Effects of the Pea Defensin Psd1 in the Caco-2/Immune Cells Co-Culture uponInternational journal of molecular sciences · 2023Article
- Type I interferons during host-fungus interactions: Is antifungal immunity going viral?PLoS pathogens · 2022Article
- The network interplay of interferon and Toll-like receptor signaling pathways in the anti-Candida immune response.Scientific reports · 2021Article
- Article
- The IL-27 receptor regulates TIGIT on memory CD4iScience · 2021Article
- Dependence on Mincle and Dectin-2 Varies With MultipleFrontiers in microbiology · 2021Article
- New chimeric TLR7/NOD2 agonist is a potent adjuvant to induce mucosal immune responses.EBioMedicine · 2020Article
- Performance of a new Candida anti-mannan IgM and IgG assays in the diagnosis of candidemia.Revista do Instituto de Medicina Tropical de Sao Paulo · 2020Article
- Article
- Pattern recognition receptors in fungal immunity.Seminars in cell & developmental biology · 2019Review
- Candida parapsilosis: from Genes to the Bedside.Clinical microbiology reviews · 2019Review
- Dependence on Dectin-1 Varies With MultipleFrontiers in microbiology · 2019Article
- Review
- IL-27: a double agent in the IL-6 family.Clinical and experimental immunology · 2018Review
- Differential susceptibility of Dectin-1 isoforms to functional inactivation by neutrophil and fungal proteases.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Pathogenic Effects of IFIT2 and Interferon-β during Fatal Systemic Candida albicans Infection.mBio · 2018Article
- X-linked TLR7 gene polymorphisms are associated with diverse immunological conditions but not with discoid lupus erythematosus in Polish patients.Postepy dermatologii i alergologii · 2018Article
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Authors and funding
14 authors at 5 institutions in 5 countries.
Funding
Abstract
Candida spp. elicit cytokine production downstream of various pathogen recognition receptors, including C-type lectin-like receptors, TLRs, and nucleotide oligomerization domain (NOD)-like receptors. IL-12 family members IL-12p70 and IL-23 are important for host immunity against Candida spp. In this article, we show that IL-27, another IL-12 family member, is produced by myeloid cells in response to selected Candida spp. We demonstrate a novel mechanism for Candida parapsilosis-mediated induction of IL-27 in a TLR7-, MyD88-, and NOD2-dependent manner. Our data revealed that IFN-β is induced by C. parapsilosis, which in turn signals through the IFN-α/β receptor and STAT1/2 to induce IL-27. Moreover, IL-27R (WSX-1)-deficient mice systemically infected with C. parapsilosis displayed enhanced pathogen clearance compared with wild-type mice. This was associated with increased levels of proinflammatory cytokines in the serum and increased IFN-γ and IL-17 responses in the spleens of IL-27R-deficient mice. Thus, our data define a novel link between C. parapsilosis, TLR7, NOD2, IFN-β, and IL-27, and we have identified an important role for IL-27 in the immune response against C. parapsilosis Overall, these findings demonstrate an important mechanism for the suppression of protective immune responses during infection with C. parapsilosis, which has potential relevance for infections with other fungal pathogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.