Evidence map›Paper›PMID 27259584›Full record

SynthesisBrain structure & function2017

Task modulated brain connectivity of the amygdala: a meta-analysis of psychophysiological interactions.

Xin Di, Jia Huang, Bharat B Biswal

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Brain structure & function, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  18. Childhood Adversity and Neural Development: A Systematic Review.Annual review of developmental psychology · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xin DiDepartment of Biomedical Engineering, New Jersey Institute of Technology, 607 Fenster Hall, University Height, Newark, NJ, 07102, USA.
Jia HuangInstitute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Beijing, 100101, People's Republic of China.
Bharat B BiswalDepartment of Biomedical Engineering, New Jersey Institute of Technology, 607 Fenster Hall, University Height, Newark, NJ, 07102, USA. bbiswal@yahoo.com.

Funding

Functional MRI of Aging: Biophysical CharacterizationR01AG032088 · NIA · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI BISWAL, BHARAT BHUSAN · 2010 to 2014
$1.5M
CRCNS: Neurophysiological Basis of Brain ConnectivityR01DA038895 · NIDA · NEW JERSEY INSTITUTE OF TECHNOLOGY · PI BISWAL, BHARAT BHUSAN · 2014 to 2016
$381k
NIA NIH HHS R01 AG032088NIDA NIH HHS R01 DA038895
6 · The paper itself

Abstract

Understanding functional connectivity of the amygdala with other brain regions, especially task modulated connectivity, is a critical step toward understanding the role of the amygdala in emotional processes and the interactions between emotion and cognition. The present study performed coordinate-based meta-analysis on studies of task modulated connectivity of the amygdala which used psychophysiological interaction (PPI) analysis. We first analyzed 49 PPI studies on different types of tasks using activation likelihood estimation (ALE) meta-analysis. Widespread cortical and subcortical regions showed consistent task modulated connectivity with the amygdala, including the medial frontal cortex, bilateral insula, anterior cingulate, fusiform gyrus, parahippocampal gyrus, thalamus, and basal ganglia. These regions were in general overlapped with those showed coactivations with the amygdala, suggesting that these regions and amygdala are not only activated together, but also show different levels of interactions during tasks. Further analyses with subsets of PPI studies revealed task specific functional connectivities with the amygdala that were modulated by fear processing, face processing, and emotion regulation. These results suggest a dynamic modulation of connectivity upon task demands, and provide new insights on the functions of the amygdala in different affective and cognitive processes. The meta-analytic approach on PPI studies may offer a framework toward systematical examinations of task modulated connectivity.

Indexed as

AmygdalaBrainBrain MappingCognitionEmotionsHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingNeural PathwaysAmygdalaConnectivityDynamic connectivityfMRIPsychophysiological interactionTask modulation

Identifiers

PMID27259584
PMCPMC10673661

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.