Evidence map›Paper›PMID 27259550›Full record

ReviewStem cell research & therapy2016

Mesenchymal stem cells in cardiac regeneration: a detailed progress report of the last 6 years (2010-2015).

Aastha Singh, Abhishek Singh, Dwaipayan Sen

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cell research & therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04011059 (Randomized Study as Proof of Concept of Coronary Revascularization Surgery With Injection of Wharton's Jelly-derived Mesenchymal Cells and Placement of an Epicardial Extracellular Matrix Patch Seeded With WJ-MSCs in Patients With Ischemic Cardiomyopathy), which is not on this map. Cited by 102 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04011059 phase1 / phase2unknown statusnot on this mapstarted 2019, after this paper: background citation

Randomized Study as Proof of Concept of Coronary Revascularization Surgery With Injection of Wharton's Jelly-derived Mesenchymal Cells and Placement of an Epicardial Extracellular Matrix Patch Seeded With WJ-MSCs in Patients With Ischemic Cardiomyopathy

TypeinterventionalSponsorHospital San Vicente FundaciónRan2019 to 2023Enrolled40ConditionsCardiovascular Diseases, Heart Failure, Coronary Artery Disease, Mesenchymal Stem Cell TransplantationArmsWharton's jelly-derived mesenchymal cells
3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  19. Stem Cell-Based Therapeutic Approaches in Genetic Diseases.Advances in experimental medicine and biology · 2023
    Article
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42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Aastha SinghSchool of Bio Sciences and Technology, VIT University, Vellore, India.
Abhishek SinghSchool of Bio Sciences and Technology, VIT University, Vellore, India.
Dwaipayan SenSchool of Bio Sciences and Technology, VIT University, Vellore, India. dwaipayan.sen@vit.ac.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stem cells have been used for cardiovascular regenerative therapy for decades. These cells have been established as one of the potential therapeutic agents, following several tests in animal models and clinical trials. In the process, various sources of mesenchymal stem cells have been identified which help in cardiac regeneration by either revitalizing the cardiac stem cells or revascularizing the arteries and veins of the heart. Although mesenchymal cell therapy has achieved considerable admiration, some challenges still remain that need to be overcome in order to establish it as a successful technique. This in-depth review is an attempt to summarize the major sources of mesenchymal stem cells involved in myocardial regeneration, the significant mechanisms involved in the process with a focus on studies (human and animal) conducted in the last 6 years and the challenges that remain to be addressed.

Indexed as

Mesenchymal Stem Cell TransplantationAnimalsBiomarkersCell- and Tissue-Based TherapyClinical Trials as TopicGene ExpressionHumansMesenchymal Stem CellsMyocardial InfarctionMyocardiumNeovascularization, PhysiologicRegenerationRegenerative MedicineResearch ReportStem Cell NicheBiomarkersCardiac regenerationCell therapyCell transplantationMesenchymal stem cellsNiche hypothesis

Identifiers

PMID27259550
PMCPMC4893234

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.