ArticleVirchows Archiv : an international journal of pathology2016
Somatic mutations in histiocytic sarcoma identified by next generation sequencing.
Article in Virchows Archiv : an international journal of pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 57 citations in OpenAlex.
- Histiocytic sarcoma with a common clonal origin emerged after 33 years from B-cell precursor acute lymphoblastic leukemia.Journal of clinical and experimental hematopathology : JCEH · 2026Article
- Misdiagnosed Histiocytic Sarcoma: A Case Report.Clinical case reports · 2025Article
- A rare case of primary central nervous system histiocytic sarcoma harboring a novel ARHGAP45::BRAF fusion: a case report and literature review.Brain tumor pathology · 2024Review
- Whole exome and transcriptome analysis revealed the activation of ERK and Akt signaling pathway in canine histiocytic sarcoma.Scientific reports · 2023Article
- Primary splenic histiocytic sarcoma successfully treated with splenectomy: a case report and literature review.International cancer conference journal · 2022Article
- Small bowel and lung histiocytic sarcoma revealed by acute peritonitis: A case report with review of literature.Annals of medicine and surgery (2012) · 2021Article
- Molecular and immunophenotypic characterization of anal squamous cell carcinoma reveals distinct clinicopathologic groups associated with HPV and TP53 mutation status.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021Article
- Pediatric Lymphoid and Histiocytic Lesions in the Head and Neck.Head and neck pathology · 2021Review
- Genomic profiling of primary histiocytic sarcoma reveals two molecular subgroups.Haematologica · 2020Article
- Subsequent development of histiocytic sarcoma and follicular lymphoma: cytogenetics and next-generation sequencing analyses provide evidence for transdifferentiation of early common lymphoid precursor-a case report and review of literature.Virchows Archiv : an international journal of pathology · 2020Review
- Primary Histiocytic Sarcoma Presenting as a Breast Mass: A Case Report.Journal of breast cancer · 2019Article
- Identifying Candidate Druggable Targets in Canine Cancer Cell Lines Using Whole-Exome Sequencing.Molecular cancer therapeutics · 2019Article
- Activating Mutations inGenes · 2019Article
- Somatic molecular analysis augments cytologic evaluation of pancreatic cyst fluids as a diagnostic tool.Oncotarget · 2019Article
- Identification of diverse activating mutations of the RAS-MAPK pathway in histiocytic sarcoma.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2019Article
- Rare myeloid sarcoma with KMT2A (MLL)-ELL fusion presenting as a vaginal wall mass.Diagnostic pathology · 2019Article
- A case of recurrent histiocytic sarcoma with MAP2K1 pathogenic variant treated with the MEK inhibitor trametinib.International journal of hematology · 2019Article
- Malignant fibrous histiocytoma, now referred to as Undifferentiated Pleomorphic Sarcoma: A Case Report of an unexpected histology of a subcutaneous lesion.International journal of surgery case reports · 2019Article
- Histiocytic cell neoplasms involving the bone marrow: summary of the workshop cases submitted to the 18th Meeting of the European Association for Haematopathology (EAHP) organized by the European Bone Marrow Working Group, Basel 2016.Annals of hematology · 2018Article
- Canine sarcomas as a surrogate for the human disease.Pharmacology & therapeutics · 2018Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Histiocytic sarcoma is a rare malignant neoplasm of presumed hematopoietic origin showing morphologic and immunophenotypic evidence of histiocytic differentiation. Somatic mutation importance in the pathogenesis or disease progression of histiocytic sarcoma was largely unknown. To identify somatic mutations in histiocytic sarcoma, we studied 5 histiocytic sarcomas [3 female and 2 male patients; mean age 54.8 (20-72), anatomic sites include lymph node, uterus, and pleura] and matched normal tissues from each patient as germ line controls. Somatic mutations in 50 "Hotspot" oncogenes and tumor suppressor genes were examined using next generation sequencing. Three (out of five) histiocytic sarcoma cases carried somatic mutations in BRAF. Among them, G464V [variant frequency (VF) of 43.6 %] and G466R (VF of 29.6 %) located at the P loop potentially interfere with the hydrophobic interaction between P and activating loops and ultimately activation of BRAF. Also detected was BRAF somatic mutation N581S (VF of 7.4 %), which was located at the catalytic loop of BRAF kinase domain: its role in modifying kinase activity was unclear. A similar mutational analysis was also performed on nine acute monocytic/monoblastic leukemia cases, which did not identify any BRAF somatic mutations. Our study detected several BRAF mutations in histiocytic sarcomas, which may be important in understanding the tumorigenesis of this rare neoplasm and providing mechanisms for potential therapeutical opportunities.
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