ArticleBioconjugate chemistry2016
Axial PEGylation of Tin Octabutoxy Naphthalocyanine Extends Blood Circulation for Photoacoustic Vascular Imaging.
Article in Bioconjugate chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Micelle-Encapsulated Theranostic Phthalocyanine and Naphthalocyanine Derivatives for Photothermal Therapy and Photoacoustic Imaging with NIR-I vs NIR-II Irradiation.ACS applied nano materials · 2025Article
- Dual Emissive Zn(II) Naphthalocyanines: Synthesis, Structural and Photophysical Characterization with Theory-Supported Insights towards Soluble Coordination Compounds with Visible and Near-Infrared Emission.International journal of molecular sciences · 2024Article
- Choice of Nanoparticles for Theranostics Engineering: Surface Coating to Nanovalves Approach.Nanotheranostics · 2024Review
- Theranostic Phthalocyanine and Naphthalocyanine Nanoparticles for Photoacoustic Imaging and Photothermal Therapy of Tumors.Nanotheranostics · 2024Article
- Optimizing Axial and Peripheral Substitutions in Si-Centered Naphthalocyanine Dyes for Enhancing Aqueous Solubility and Photoacoustic Signal Intensity.International journal of molecular sciences · 2023Article
- Intraperitoneal administration for sustained photoacoustic contrast agent imaging.Photoacoustics · 2022Article
- Biomedical Photoacoustic Imaging for Molecular Detection and Disease Diagnosis: "Always-On" and "Turn-On" Probes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- New contrast agents for photoacoustic imaging and theranostics: Recent 5-year overview on phthalocyanine/naphthalocyanine-based nanoparticles.APL bioengineering · 2021Review
- Fluorescent Nanoparticles Coated with a Somatostatin Analogue Target Blood Monocyte for Efficient Leukaemia Treatment.Pharmaceutical research · 2020Article
- A Review of Endogenous and Exogenous Contrast Agents Used in Photoacoustic Tomography with Different Sensing Configurations.Sensors (Basel, Switzerland) · 2020Review
- Photoacoustic Imaging Probes Based on Tetrapyrroles and Related Compounds.International journal of molecular sciences · 2020Review
- Copper-64 Labeled PEGylated Exosomes for In Vivo Positron Emission Tomography and Enhanced Tumor Retention.Bioconjugate chemistry · 2019Article
- Metalloporphyrin-indomethacin conjugates as new photosensitizers for photodynamic therapy.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2019Article
- Targeting of somatostatin receptors expressed in blood cells using quantum dots coated with vapreotide.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2018Article
- Molecular Photoacoustic Contrast Agents: Design Principles & Applications.Photochemistry and photobiology · 2018Review
- Ingestible roasted barley for contrast-enhanced photoacoustic imaging in animal and human subjects.Biomaterials · 2018Article
- Naphthalocyanines as contrast agents for photoacoustic and multimodal imaging.Biomedical engineering letters · 2018Review
- Towards optimized naphthalocyanines as sonochromes for photoacoustic imagingPhotoacoustics · 2018Article
- Implantable Tin Porphyrin-PEG Hydrogels with pH-Responsive Fluorescence.Biomacromolecules · 2017Article
- In vivo photoacoustic tumor tomography using a quinoline-annulated porphyrin as NIR molecular contrast agent.Organic & biomolecular chemistry · 2017Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Attachment of polyethylene glycol (PEG) can prolong blood circulation of biological molecules, a useful trait for a vascular imaging agent. Here, we present a route for modifying octabutoxy naphthalocyanine (ONc) with PEG, via axial conjugation following ONc chelation with Sn(IV) chloride (Sn-ONc). Tin chelation caused ONc absorbance to shift from 860 to 930 nm. Hydroxy terminated PEG was treated with sodium and then was axially attached to the tin, generating PEG-Sn-ONc. Unlike ONc or Sn-ONc, PEG-Sn-ONc was soluble in methanol. ONc and PEG-Sn-ONc were dissolved in polysorbate solutions and administered to mice intravenously. PEG-Sn-ONc demonstrated substantially longer blood circulation time than ONc, with a 4 times longer half-life and a nearly 10 times greater area under the curve. PEG-Sn-ONc gave rise to photoacoustic contrast and could be used for noninvasive brain vessel imaging even 24 h following injection. This work demonstrates that nonmetallic naphthalocyanines can be chelated with tin, and be axially modified with PEG for enhanced circulation times for long-term vascular imaging with photoacoustic tomography.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.