ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2017
Anisotropic cerebral vascular architecture causes orientation dependency in cerebral blood flow and volume measured with dynamic susceptibility contrast magnetic resonance imaging.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- The relationship of white matter tract orientation to vascular geometry in the human brain.Scientific reports · 2025Article
- Temporal Shift When Comparing Contrast-Agent Concentration Curves Estimated Using Quantitative Susceptibility Mapping (QSM) and ΔR2*: The Association Between Vortex Parameters and Oxygen Extraction Fraction.Tomography (Ann Arbor, Mich.) · 2025Article
- The relationship of white matter tract orientation to vascular geometry in the human brain.bioRxiv : the preprint server for biology · 2025Article
- Linking neuron-axon-synapse architecture to white matter vasculature using high-resolution multimodal MRI in primate brain.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- The Road to a Realistic 3D Model for Estimating RNMR in biomedicine · 2025Article
- High-fidelity intravoxel incoherent motion parameter mapping using locally low-rank and subspace modeling.NeuroImage · 2024Article
- Dynamic fluctuations in brain iron content during migraine attacks: insights from relaxometry and diffusion tensor imaging.Frontiers in neurology · 2024Article
- Streamlined quantitative BOLD for detecting visual stimulus-induced changes in oxygen extraction fraction in healthy participants: toward clinical application in human glioma.Magma (New York, N.Y.) · 2023Article
- Static and dynamic BOLD fMRI components along white matter fibre tracts and their dependence on the orientation of the local diffusion tensor axis relative to the BJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Magnetic susceptibility anisotropy in normal appearing white matter in multiple sclerosis from single-orientation acquisition.NeuroImage. Clinical · 2022Article
- Brain microvasculature has a common topology with local differences in geometry that match metabolic load.Neuron · 2021Article
- Myelin water imaging depends on white matter fiber orientation in the human brain.Magnetic resonance in medicine · 2021Article
- Voxelized simulation of cerebral oxygen perfusion elucidates hypoxia in aged mouse cortex.PLoS computational biology · 2021Article
- Characterizing white matter fiber orientation effects on multi-parametric quantitative BOLD assessment of oxygen extraction fraction.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Resting-state connectivity stratifies premanifest Huntington's disease by longitudinal cognitive decline rate.Scientific reports · 2020Article
- White Matter Neuroplasticity: Motor Learning Activates the Internal Capsule and Reduces Hemodynamic Response Variability.Frontiers in human neuroscience · 2020Article
- Perivascular space fluid contributes to diffusion tensor imaging changes in white matter.NeuroImage · 2019Article
- Dependence of resting-state fMRI fluctuation amplitudes on cerebral cortical orientation relative to the direction of B0 and anatomical axes.NeuroImage · 2019Article
- Poster Viewing Sessions PA00-A01 to PA00-A49.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- Preclinical Imaging Biomarkers for Postischaemic Neurovascular Remodelling.Contrast media & molecular imaging · 2019Review
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Authors and funding
10 authors.
Funding
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Abstract
Measurements of cerebral perfusion using dynamic susceptibility contrast magnetic resonance imaging rely on the assumption of isotropic vascular architecture. However, a considerable fraction of vessels runs in parallel with white matter tracts. Here, we investigate the effects of tissue orientation on dynamic susceptibility contrast magnetic resonance imaging. Tissue orientation was measured using diffusion tensor imaging and dynamic susceptibility contrast was performed with gradient echo planar imaging. Perfusion parameters and the raw dynamic susceptibility contrast signals were correlated with tissue orientation. Additionally, numerical simulations were performed for a range of vascular volumes of both the isotropic vascular bed and anisotropic vessel components, as well as for a range of contrast agent concentrations. The effect of the contrast agent was much larger in white matter tissue perpendicular to the main magnetic field compared to white matter parallel to the main magnetic field. In addition, cerebral blood flow and cerebral blood volume were affected in the same way with angle-dependent variations of up to 130%. Mean transit time and time to maximum of the residual curve exhibited weak orientation dependency of 10%. Numerical simulations agreed with the measured data, showing that one-third of the white matter vascular volume is comprised of vessels running in parallel with the fibre tracts.
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