ArticleThorax2016
Altered breathing mechanics and ventilatory response during exercise in children born extremely preterm.
Article in Thorax, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Physiological responses to exercise in survivors of preterm birth: a meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- Lung volumes, gas transfer and oscillometry after preterm birth: systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- Impaired lung function and associated risk factors in children born prematurely: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2024Pooled it
- Long-term pulmonary outcomes in BPD throughout the life-course.Journal of perinatology : official journal of the California Perinatal Association · 2026Review
- Cardiopulmonary Exercise Performance of Children Born Non-Extremely Preterm.Children (Basel, Switzerland) · 2024Article
- Impact of premature birth on cardiopulmonary function in later life.European journal of pediatrics · 2023Article
- Increasing airway obstruction through life following bronchopulmonary dysplasia: a meta-analysis.ERJ open research · 2023Review
- Preterm birth and exercise capacity: what do we currently know?Frontiers in pediatrics · 2023Review
- Cardiopulmonary Exercise Testing in Childhood in Late Preterms: Comparison to Early Preterms and Term-Born Controls.Journal of personalized medicine · 2022Article
- Endotypes of Prematurity and Phenotypes of Bronchopulmonary Dysplasia: Toward Personalized Neonatology.Journal of personalized medicine · 2022Review
- Physiological aspects of cardiopulmonary dysanapsis on exercise in adults born preterm.The Journal of physiology · 2022Review
- Effects of Pre-Term Birth on the Cardio-Respiratory Responses to Hypoxic Exercise in Children.Life (Basel, Switzerland) · 2022Article
- Lung growth and pulmonary function after prematurity and bronchopulmonary dysplasia.Pediatric pulmonology · 2021Review
- Bronchopulmonary dysplasia as a determinant of respiratory outcomes in adult life.Pediatric pulmonology · 2021Article
- Perinatal Hypoxemia and Oxygen Sensing.Comprehensive Physiology · 2021Article
- Lung abnormalities do not influence aerobic capacity in school children born preterm.European journal of applied physiology · 2021Article
- Perinatal Hypoxia-Inducible Factor Stabilization Preserves Lung Alveolar and Vascular Growth in Experimental Bronchopulmonary Dysplasia.American journal of respiratory and critical care medicine · 2020Article
- Early origins of lung disease: towards an interdisciplinary approach.European respiratory review : an official journal of the European Respiratory Society · 2020Review
- Phenotypes of Bronchopulmonary Dysplasia.International journal of molecular sciences · 2020Review
- Transcriptional profiling of lung macrophages identifies a predictive signature for inflammatory lung disease in preterm infants.Communications biology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExtreme preterm birth confers risk of long-term impairments in lung function and exercise capacity. There are limited data on the factors contributing to exercise limitation following extreme preterm birth. This study examined respiratory mechanics and ventilatory response during exercise in a large cohort of children born extremely preterm (EP).
methodsThis cohort study included children 8-12 years of age who were born EP (≤28 weeks gestation) between 1997 and 2004 and treated in a large regionalised neonatal intensive care unit in western Canada. EP children were divided into no/mild bronchopulmonary dysplasia (BPD) (ie, supplementary oxygen or ventilation ceased before 36 weeks gestational age; n=53) and moderate/severe BPD (ie, continued supplementary oxygen or ventilation at 36 weeks gestational age; n=50). Age-matched control children (n=65) were born at full term. All children attempted lung function and cardiopulmonary exercise testing measurements.
resultsCompared with control children, EP children had lower airway flows and diffusion capacity but preserved total lung capacity. Children with moderate/severe BPD had evidence of gas trapping relative to other groups. The mean difference in exercise capacity (as measured by oxygen uptake (VO
conclusionsExpiratory flow limitation and an exaggerated ventilatory response contribute to respiratory limitation to exercise in children born EP with moderate/severe BPD.
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Registered trials
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