ArticleHuman brain mapping2016
Alterations in regional shape on ipsilateral and contralateral cortex contrast in children with unilateral cerebral palsy and are predictive of multiple outcomes.
Article in Human brain mapping, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Neural Correlates of Mobility in Children with Cerebral Palsy: A Systematic Review.International journal of environmental research and public health · 2024Pooled it
- Feasibility of Non-Sedate Magnetic Resonance Imaging for Children with Cerebral Palsy: Tolerance and Structural Analysis Considerations.Children (Basel, Switzerland) · 2026Article
- Disruptions of morphological brain networks and their associations with multi-symptoms in children with spastic cerebral palsy.Quantitative imaging in medicine and surgery · 2025Article
- Reduced brainstem volume is associated with mobility impairments in youth with cerebral palsy.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2023Article
- Alterations in cortical morphometry of the contralesional hemisphere in children, adolescents, and young adults with perinatal stroke.Scientific reports · 2023Article
- Reduced Brainstem Volume is Associated with Mobility Impairments in Youth with Cerebral Palsy.Research square · 2023Article
- White matter microstructure and receptive vocabulary in children with cerebral palsy: The role of interhemispheric connectivity.PloS one · 2023Article
- Development and validation of a novel model based on hand knob score and white matter injury on MRI to predict hand function in children with cerebral palsy.Annals of translational medicine · 2022Article
- A ValHeliyon · 2022Article
- Altered Somatosensory Cortical Activity Is Associated with Cortical Thickness in Adults with Cerebral Palsy: Multimodal Evidence from MEG/sMRI.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Article
- Understanding the impact of bilateral brain injury in children with unilateral cerebral palsy.Human brain mapping · 2020Article
- Article
- Structural and functional connectivity of motor circuits after perinatal stroke: A machine learning study.NeuroImage. Clinical · 2020Article
- Treatment response prediction of rehabilitation program in children with cerebral palsy using radiomics strategy: protocol for a multicenter prospective cohort study in west China.Quantitative imaging in medicine and surgery · 2019Article
- Abnormal Gray Matter Structural Covariance Networks in Children With Bilateral Cerebral Palsy.Frontiers in human neuroscience · 2019Article
- Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Congenital brain lesions result in a wide range of cerebral tissue alterations observed in children with cerebral palsy (CP) that are associated with a range of functional impairments. The relationship between injury severity and functional outcomes, however, remains poorly understood. This research investigates the differences in cortical shape between children with congenital brain lesions and typically developing children (TDC) and investigates the correlations between cortical shape and functional outcome in a large cohort of patients diagnosed with unilateral CP. Using 139 structural magnetic resonance images, including 95 patients with clinically diagnosed CP and 44 TDC, cortical segmentations were obtained using a modified expectation maximization algorithm. Three shape characteristics (cortical thickness, curvature, and sulcal depth) were computed within a number of cortical regions. Significant differences in these shape measures compared to the TDC were observed on both the injured hemisphere of children with CP (P < 0.004), as well as on the apparently uninjured hemisphere, illustrating potential compensatory mechanisms in these children. Furthermore, these shape measures were significantly correlated with several functional outcomes, including motor, cognition, vision, and communication (P < 0.012), with three out of these four models performing well on test set validation. This study highlights that cortical neuroplastic effects may be quantified using MR imaging, allowing morphological changes to be studied longitudinally, including any influence of treatment. Ultimately, such approaches could be used for the long term prediction of outcomes and the tailoring of treatment to individuals. Hum Brain Mapp 37:3588-3603, 2016. © 2016 Wiley Periodicals, Inc.
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