ArticleNanotoxicology2016
Multilaboratory evaluation of 15 bioassays for (eco)toxicity screening and hazard ranking of engineered nanomaterials: FP7 project NANOVALID.
Article in Nanotoxicology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Cement Industry Pollution Mitigation: A Comprehensive Review on Reducing Environmental and Health Impacts.Toxics · 2026Review
- Next-generation nanomaterials for environmental remediation: smart design, hybrid materials and sustainable use.Frontiers in chemistry · 2026Review
- Comparable biochemical responses of three Scenedesmus species to NiO and ZnO nanoparticles exposure.Scientific reports · 2025Article
- Well-Characterized Polyethyleneimine-/Carboxylated-Polyethylene-Glycol-Functionalized Gold Nanoparticles as Prospective Nanoscale Control Materials for In Vitro Cell Viability Assays: Particle Characterization and Toxicity Tests in Eight Mammalian Cell Lines.Nanomaterials (Basel, Switzerland) · 2025Article
- Antimicrobial Activity of Amino-Modified Cellulose Nanofibrils Decorated with Silver Nanoparticles.Journal of functional biomaterials · 2024Article
- Characterization and Behaviour of Silica Engineered Nanocontainers in Low and High Ionic Strength Media.Nanomaterials (Basel, Switzerland) · 2023Article
- Molluscicidal and antioxidant activities of silver nanoparticles on the multi-species of snail intermediate hosts of schistosomiasis.PLoS neglected tropical diseases · 2022Article
- Biogenic synthesis of selenium and tellurium nanoparticles by marine bacteria and their biological activity.World journal of microbiology & biotechnology · 2022Article
- The effects of copper ions and copper nanomaterials on the output of amino acids from marine microalgae.Environmental science and pollution research international · 2022Article
- Nanomaterials, a New Challenge in the Workplace.Advances in experimental medicine and biology · 2022Article
- Nanotoxicology and Nanomedicine: The Yin and Yang of Nano-Bio Interactions for the New Decade.Nano today · 2021Article
- Ecotoxicity to Freshwater Organisms and Cytotoxicity of Nanomaterials: Are We Generating Sufficient Data for Their Risk Assessment?Nanomaterials (Basel, Switzerland) · 2020Article
- Bioconcentration of Organotin Cations during Molting InhibitsEnvironmental science & technology · 2020Article
- Surface carboxylation or PEGylation decreases CuO nanoparticles' cytotoxicity to human cells in vitro without compromising their antibacterial properties.Archives of toxicology · 2020Article
- Evaluation of Ecotoxicology Assessment Methods of Nanomaterials and Their Effects.Nanomaterials (Basel, Switzerland) · 2020Review
- An insight into the dependency on sample preparation for (eco) toxicity assessment of TiOEnvironmental monitoring and assessment · 2020Article
- In Vitro Cytotoxicity Evaluation of the Magnéli Phase Titanium Suboxides (TiInternational journal of molecular sciences · 2019Article
- The impact of morphology and size of zinc oxide nanoparticles on its toxicity to the freshwater microalga, Raphidocelis subcapitata.Environmental science and pollution research international · 2019Article
- Combined Effects of Test Media and Dietary Algae on the Toxicity of CuO and ZnO Nanoparticles to Freshwater MicrocrustaceansNanomaterials (Basel, Switzerland) · 2018Article
- Plasma membrane is the target of rapid antibacterial action of silver nanoparticles inInternational journal of nanomedicine · 2018Article
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Within EU FP7 project NANOVALID, the (eco)toxicity of 7 well-characterized engineered nanomaterials (NMs) was evaluated by 15 bioassays in 4 laboratories. The highest tested nominal concentration of NMs was 100 mg/l. The panel of the bioassays yielded the following toxicity order: Ag > ZnO > CuO > TiO2 > MWCNTs > SiO2 > Au. Ag, ZnO and CuO proved very toxic in the majority of assays, assumingly due to dissolution. The latter was supported by the parallel analysis of the toxicity of respective soluble metal salts. The most sensitive tests/species were Daphnia magna (towards Ag NMs, 24-h EC50 = 0.003 mg Ag/l), algae Raphidocelis subcapitata (ZnO and CuO, 72-h EC50 = 0.14 mg Zn/l and 0.7 mg Cu/l, respectively) and murine fibroblasts BALB/3T3 (CuO, 48-h EC50 = 0.7 mg Cu/l). MWCNTs showed toxicity only towards rat alveolar macrophages (EC50 = 15.3 mg/l) assumingly due to high aspect ratio and TiO2 towards R. subcapitata (EC50 = 6.8 mg Ti/l) due to agglomeration of TiO2 and entrapment of algal cells. Finally, we constructed a decision tree to select the bioassays for hazard ranking of NMs. For NM testing, we recommend a multitrophic suite of 4 in vitro (eco)toxicity assays: 48-h D. magna immobilization (OECD202), 72-h R. subcapitata growth inhibition (OECD201), 30-min Vibrio fischeri bioluminescence inhibition (ISO2010) and 48-h murine fibroblast BALB/3T3 neutral red uptake in vitro (OECD129) representing crustaceans, algae, bacteria and mammalian cells, respectively. Notably, our results showed that these assays, standardized for toxicity evaluation of "regular" chemicals, proved efficient also for shortlisting of hazardous NMs. Additional assays are recommended for immunotoxicity evaluation of high aspect ratio NMs (such as MWCNTs).
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