ArticleChemistry (Weinheim an der Bergstrasse, Germany)2016
A New Ir-NHC Catalyst for Signal Amplification by Reversible Exchange in D2 O.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- IrTMes - a stable SABRE catalyst for the hyperpolarization of [1-The Analyst · 2026Article
- Label-Free Measurement of Ligand Interactions Using SABRE Hyperpolarization at Low Magnetic Fields.Analytical chemistry · 2026Article
- High HThe journal of physical chemistry letters · 2025Article
- Article
- Water-Compatible and Recyclable Heterogeneous SABRE Catalyst for NMR Signal Amplification.JACS Au · 2023Article
- Spin Hyperpolarization in Modern Magnetic Resonance.Chemical reviews · 2023Review
- Efficient SABRE-SHEATH Hyperpolarization of Potent Branched-Chain-Amino-Acid Metabolic Probe [1-Metabolites · 2023Article
- SABRE Hyperpolarization with up to 200 bar Parahydrogen in Standard and Quickly Removable Solvents.International journal of molecular sciences · 2023Article
- Hyperpolarizing DNA Nucleobases via NMR Signal Amplification by Reversible Exchange.Molecules (Basel, Switzerland) · 2023Article
- Metabolic Tumor Imaging with Rapidly Signal-Enhanced 1-Chemphyschem : a European journal of chemical physics and physical chemistry · 2023Article
- Catalyst-Free Aqueous Hyperpolarized [1-ACS sensors · 2022Article
- RapidAnalytical chemistry · 2022Article
- Analysis of Complex Mixtures by Chemosensing NMR UsingAccounts of chemical research · 2022Article
- Advancing homogeneous catalysis for parahydrogen-derived hyperpolarisation and its NMR applications.Chemical science · 2022Review
- Rapid SABRE Catalyst Scavenging Using Functionalized Silicas.Molecules (Basel, Switzerland) · 2022Article
- Hyperpolarisation of weakly binding N-heterocycles using signal amplification by reversible exchange.Chemical science · 2021Article
- Reversible Hyperpolarization of Ketoisocaproate Using Sulfoxide-containing Polarization Transfer Catalysts.Chemphyschem : a European journal of chemical physics and physical chemistry · 2021Article
- Rational ligand choice extends the SABRE substrate scope.Chemical communications (Cambridge, England) · 2020Article
- Optimisation of pyruvate hyperpolarisation using SABRE by tuning the active magnetisation transfer catalyst.Catalysis science & technology · 2020Article
- Hyperpolarising Pyruvate through Signal Amplification by Reversible Exchange (SABRE).Angewandte Chemie (International ed. in English) · 2019Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
NMR signal amplification by reversible exchange (SABRE) has been observed for pyridine, methyl nicotinate, N-methylnicotinamide, and nicotinamide in D2 O with the new catalyst [Ir(Cl)(IDEG)(COD)] (IDEG=1,3-bis(3,4,5-tris(diethyleneglycol)benzyl)imidazole-2-ylidene). During the activation and hyperpolarization steps, exclusively D2 O was used, resulting in the first fully biocompatible SABRE system. Hyperpolarized (1) H substrate signals were observed at 42.5 MHz upon pressurizing the solution with parahydrogen at close to the Earth's magnetic field, at concentrations yielding barely detectable thermal signals. Moreover, 42-, 26-, 22-, and 9-fold enhancements were observed for nicotinamide, pyridine, methyl nicotinate, and N-methylnicotinamide, respectively, in conventional 300 MHz studies. This research opens up new opportunities in a field in which SABRE has hitherto primarily been conducted in CD3 OD. This system uses simple hardware, leaves the substrate unaltered, and shows that SABRE is potentially suitable for clinical purposes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.